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- EIF1AX abstract "Eukaryotic translation initiation factor 1A, X-chromosomal is a protein that in humans is encoded by the EIF1AX gene.Mammalian 17-kDa eukaryotic initiation factor, eIF1A (formerly designated eIF-4C), is essential for transfer of the initiator Met-tRNAf (as Met-tRNAf·eIF2·GTP ternary complex) to 40 S ribosomal subunits in the absence of mRNA to form the 40 S preinitiation complex (40 S·Met-tRNAf·eIF2·GTP). Furthermore, eIF1A acts catalytically in this reaction to mediate highly efficient transfer of the Met-tRNAf·eIF2·GTP ternary complex to 40 S ribosomal subunits. The 40 S complex formed is free of eIF1A which indicates that its role in 40 S preinitiation complex formation is not to stabilize the binding of Met-tRNAf to 40 S ribosomes. Additionally, the eIF1A-mediated 40 S initiation complex formed in the presence of AUG codon efficiently joins 60 S ribosomal subunits in an eIF5-dependent reaction to form a functional 80 S initiation complex. Though found in some reports, eIF1A probably plays no role either in the subunit joining reaction or in the generation of ribosomal subunits from 80 S ribosomes. The major function of eIF1A is to mediate the transfer of Met-tRNAf to 40 S ribosomal subunits to form the 40 S preinitiation complex.This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA.Mutations in this gene have been recurrently seen associated to cases of uveal melanoma with disomy 3 (http://www.ncbi.nlm.nih.gov/pubmed/23793026).".
- EIF1AX entrezgene "1964".
- EIF1AX wikiPageExternalLink 23793026)..
- EIF1AX wikiPageID "14873697".
- EIF1AX wikiPageRevisionID "591165422".
- EIF1AX hasPhotoCollection EIF1AX.
- EIF1AX requireManualInspection "no".
- EIF1AX summaryText "This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex to the 5' end of capped RNA.".
- EIF1AX updateCitations "yes".
- EIF1AX updatePage "yes".
- EIF1AX updateProteinBox "yes".
- EIF1AX updateSummary "yes".
- EIF1AX type Biomolecule.
- EIF1AX type Protein.
- EIF1AX type BiologicalObject.
- EIF1AX comment "Eukaryotic translation initiation factor 1A, X-chromosomal is a protein that in humans is encoded by the EIF1AX gene.Mammalian 17-kDa eukaryotic initiation factor, eIF1A (formerly designated eIF-4C), is essential for transfer of the initiator Met-tRNAf (as Met-tRNAf·eIF2·GTP ternary complex) to 40 S ribosomal subunits in the absence of mRNA to form the 40 S preinitiation complex (40 S·Met-tRNAf·eIF2·GTP).".
- EIF1AX label "EIF1AX".
- EIF1AX sameAs m.03g_s77.
- EIF1AX sameAs Q5323134.
- EIF1AX sameAs Q5323134.
- EIF1AX wasDerivedFrom EIF1AX?oldid=591165422.
- EIF1AX isPrimaryTopicOf EIF1AX.