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- EIF4G2 abstract "Eukaryotic translation initiation factor 4 gamma 2 (also called p97, NAT1, and DAP-5) is a protein that in humans is encoded by the EIF4G2 gene.Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.".
- EIF4G2 entrezgene "1982".
- EIF4G2 wikiPageID "14169680".
- EIF4G2 wikiPageRevisionID "591166733".
- EIF4G2 hasPhotoCollection EIF4G2.
- EIF4G2 requireManualInspection "no".
- EIF4G2 summaryText "Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F , which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.".
- EIF4G2 updateCitations "yes".
- EIF4G2 updatePage "yes".
- EIF4G2 updateProteinBox "yes".
- EIF4G2 updateSummary "yes".
- EIF4G2 type Biomolecule.
- EIF4G2 type Protein.
- EIF4G2 type BiologicalObject.
- EIF4G2 comment "Eukaryotic translation initiation factor 4 gamma 2 (also called p97, NAT1, and DAP-5) is a protein that in humans is encoded by the EIF4G2 gene.Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G.".
- EIF4G2 label "EIF4G2".
- EIF4G2 sameAs m.03cwqp8.
- EIF4G2 sameAs Q5323187.
- EIF4G2 sameAs Q5323187.
- EIF4G2 wasDerivedFrom EIF4G2?oldid=591166733.
- EIF4G2 isPrimaryTopicOf EIF4G2.