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- ENC1 abstract "Ectoderm-neural cortex protein 1 is a protein that in humans is encoded by the ENC1 gene.DNA damage and/or hyperproliferative signals activate wildtype p53 tumor suppressor protein (TP53; MIM 191170), inducing cell cycle arrest or apoptosis. Mutations that inactivate p53 occur in 50% of all tumors. Polyak et al. (1997) used serial analysis of gene expression (SAGE) to evaluate cellular mRNA levels in a colorectal cancer cell line transfected with p53. Of 7,202 transcripts identified, only 14 were expressed at levels more than 10-fold higher in p53-expressing cells than in control cells. Polyak et al. (1997) termed these genes 'p53-induced genes,' or PIGs, several of which were predicted to encode redox-controlling proteins. They noted that reactive oxygen species (ROS) are potent inducers of apoptosis. Flow cytometric analysis showed that p53 expression induces ROS production, which increases as apoptosis progresses under some conditions. The authors stated that the PIG10 gene, also called ENC1, encodes an actin-binding protein.[supplied by OMIM]".
- ENC1 entrezgene "8507".
- ENC1 wikiPageID "14881926".
- ENC1 wikiPageRevisionID "591199527".
- ENC1 hasPhotoCollection ENC1.
- ENC1 requireManualInspection "no".
- ENC1 summaryText "DNA damage and/or hyperproliferative signals activate wildtype p53 tumor suppressor protein , inducing cell cycle arrest or apoptosis. Mutations that inactivate p53 occur in 50% of all tumors. Polyak et al. used serial analysis of gene expression to evaluate cellular mRNA levels in a colorectal cancer cell line transfected with p53. Of 7,202 transcripts identified, only 14 were expressed at levels more than 10-fold higher in p53-expressing cells than in control cells. Polyak et al. termed these genes 'p53-induced genes,' or PIGs, several of which were predicted to encode redox-controlling proteins. They noted that reactive oxygen species are potent inducers of apoptosis. Flow cytometric analysis showed that p53 expression induces ROS production, which increases as apoptosis progresses under some conditions. The authors stated that the PIG10 gene, also called ENC1, encodes an actin-binding protein.[supplied by OMIM]".
- ENC1 updateCitations "yes".
- ENC1 updatePage "yes".
- ENC1 updateProteinBox "yes".
- ENC1 updateSummary "yes".
- ENC1 type Biomolecule.
- ENC1 type Protein.
- ENC1 type BiologicalObject.
- ENC1 comment "Ectoderm-neural cortex protein 1 is a protein that in humans is encoded by the ENC1 gene.DNA damage and/or hyperproliferative signals activate wildtype p53 tumor suppressor protein (TP53; MIM 191170), inducing cell cycle arrest or apoptosis. Mutations that inactivate p53 occur in 50% of all tumors. Polyak et al. (1997) used serial analysis of gene expression (SAGE) to evaluate cellular mRNA levels in a colorectal cancer cell line transfected with p53.".
- ENC1 label "ENC1".
- ENC1 label "ENC1".
- ENC1 sameAs ENC1.
- ENC1 sameAs m.03h09cl.
- ENC1 sameAs Q5323689.
- ENC1 sameAs Q5323689.
- ENC1 wasDerivedFrom ENC1?oldid=591199527.
- ENC1 isPrimaryTopicOf ENC1.