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- ER_oxidoreductin abstract "ER oxidoreductin 1 (Ero1) is an oxidoreductase enzyme that catalyses the formation and isomerization of protein disulfide bonds in the endoplasmic reticulum (ER) of eukaryotes. ER Oxidoreductin 1 (Ero1) is a conserved, luminal, glycoprotein that is tightly associated with the ER membrane, and is essential for the oxidation of protein dithiols. Since disulfide bond formation is an oxidative process, the major pathway of its catalysis has evolved to utilise oxidoreductases, which become reduced during the thiol-disulfide exchange reactions that oxidise the cysteine thiol groups of nascent polypeptides. Ero1 is required for the introduction of oxidising equivalents into the ER and their direct transfer to protein disulfide isomerase (PDI), thereby ensuring the correct folding and assembly of proteins that contain disulfide bonds in their native state.Homologues of the Saccharomyces cerevisiae Ero1 proteins have been found in all eukaryotic organisms examined, and contain seven cysteine residues that are absolutely conserved, including three that form the sequence Cys–X–X–Cys–X–X–Cys (where X can be any residue).".
- ER_oxidoreductin symbol "ERO1".
- ER_oxidoreductin thumbnail PDB_1rp4_EBI.jpg?width=300.
- ER_oxidoreductin wikiPageID "7023098".
- ER_oxidoreductin wikiPageRevisionID "601719265".
- ER_oxidoreductin caption "Structure of Ero1p, source of disulfide bonds for oxidative protein folding in the cell.".
- ER_oxidoreductin hasPhotoCollection ER_oxidoreductin.
- ER_oxidoreductin interpro "IPR007266".
- ER_oxidoreductin name "Endoplasmic reticulum oxidoreductin 1".
- ER_oxidoreductin pdb ",".
- ER_oxidoreductin pfam "PF04137".
- ER_oxidoreductin symbol "ERO1".
- ER_oxidoreductin subject Category:Biomolecules.
- ER_oxidoreductin subject Category:Enzymes.
- ER_oxidoreductin type Abstraction100002137.
- ER_oxidoreductin type Activator114723079.
- ER_oxidoreductin type Catalyst114723628.
- ER_oxidoreductin type Chemical114806838.
- ER_oxidoreductin type Compound114818238.
- ER_oxidoreductin type Enzyme114732946.
- ER_oxidoreductin type Enzymes.
- ER_oxidoreductin type Macromolecule114944888.
- ER_oxidoreductin type Material114580897.
- ER_oxidoreductin type Matter100020827.
- ER_oxidoreductin type Molecule114682133.
- ER_oxidoreductin type OrganicCompound114727670.
- ER_oxidoreductin type Part113809207.
- ER_oxidoreductin type PhysicalEntity100001930.
- ER_oxidoreductin type Protein114728724.
- ER_oxidoreductin type Relation100031921.
- ER_oxidoreductin type Substance100019613.
- ER_oxidoreductin type Thing100002452.
- ER_oxidoreductin type Unit109465459.
- ER_oxidoreductin type Biomolecule.
- ER_oxidoreductin type Protein.
- ER_oxidoreductin type BiologicalObject.
- ER_oxidoreductin comment "ER oxidoreductin 1 (Ero1) is an oxidoreductase enzyme that catalyses the formation and isomerization of protein disulfide bonds in the endoplasmic reticulum (ER) of eukaryotes. ER Oxidoreductin 1 (Ero1) is a conserved, luminal, glycoprotein that is tightly associated with the ER membrane, and is essential for the oxidation of protein dithiols.".
- ER_oxidoreductin label "ER oxidoreductin".
- ER_oxidoreductin sameAs m.0h0ssy.
- ER_oxidoreductin sameAs Q5324090.
- ER_oxidoreductin sameAs Q5324090.
- ER_oxidoreductin sameAs ER_oxidoreductin.
- ER_oxidoreductin wasDerivedFrom ER_oxidoreductin?oldid=601719265.
- ER_oxidoreductin depiction PDB_1rp4_EBI.jpg.
- ER_oxidoreductin isPrimaryTopicOf ER_oxidoreductin.
