Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Emedastine> ?p ?o. }
Showing items 1 to 68 of
68
with 100 items per page.
- Emedastine abstract "Emedastine (trade name Emadine) is a second generation[citation needed] antihistamine used in eye drops to treat allergic conjunctivitis. It acts as a H1 receptor antagonist. It works by blocking certain natural substances, histamines that cause allergic symptoms. It is used in form of the difumarate. The formation of emedastine difumarate is a white, crystalline, water-soluble fine powder. Emedasine is applied as an eye drop with 2 times a day. When the patients with allergic conjunctivitis were treated with 0.05% emedastin difumarate ophthalmic solution for six weeks, the signs and symptoms such as redness, itching and swelling of the eyes were relieved. Emedastine appears to be devoid of effects on adrenergic, dopaminergic and serotonin receptors. This drug was developed by alcon which is global medical company specializing in eye care products.Emedastine is significantly selective to H1 histamine receptors (Ki=1.3 nM), whereas its affinities for other histamine receptor are low (H2: Ki=49067 nM and H3: Ki=12430 nM ) in vitro study. Tropical ocular administration of emedastine inhibits histamine-stimulated vascular permeability in the conjunctiva as a concentration dependent manner in vitro study.The human oral bioavailability is approximately 50% and maximum plasma concentration were achieved within 1-2 hours after dosing. Emedastine is mainly metabolized by the liver. There are two primary metabolites: 5-hydroxyemedastine and 6-hydroxyemedastine. They are excreted in the urine as both free and conjugated forms. The 5'-oxoanalogs of 5-hydroxyemedastine and 6-hydroxy-emedastine and the N-oxide are also formed as minor metabolites. The elimination half-life of oral emedastine in plasma is 3-4 hours, whereas that of topical emedastine is 10 hours. Approximately 44% of the oral dose is recovered in the urine over 24 hours with only 3.6% of the dose excreted as parent drug.Emedastine should not be used in patients who are hypersensitive to any other ingredients or emedastin. Benzalkonium chloride contained in the bottle of emedastines can discolor soft contact lenses, so people who wear the lenses should be careful with using it.The most common adverse effect was headache (11%). The other minor adverse effect less than 5% of patients: asthenia, burning or stinging, bad taste, blurred vision, dry eye and tearing.".
- Emedastine atcPrefix "S01".
- Emedastine atcSuffix "GX06".
- Emedastine casNumber "87233-61-2".
- Emedastine chEBI "4779".
- Emedastine drugbank "DB01084".
- Emedastine fdaUniiCode "9J1H7Y9OJV".
- Emedastine iupacName "1-(2-ethoxyethyl)-2- (4-methyl-1,4-diazepan-1-yl)- benzoimidazole".
- Emedastine pubchem "3219".
- Emedastine thumbnail Emedastine.png?width=300.
- Emedastine wikiPageID "4787359".
- Emedastine wikiPageRevisionID "585939637".
- Emedastine atcPrefix "S01".
- Emedastine atcSuffix "GX06".
- Emedastine c "17".
- Emedastine casNumber "87233".
- Emedastine chebi "4779".
- Emedastine chembl "594".
- Emedastine chemspiderid "3106".
- Emedastine drugbank "DB01084".
- Emedastine h "26".
- Emedastine hasPhotoCollection Emedastine.
- Emedastine inchi "1".
- Emedastine inchikey "KBUZBQVCBVDWKX-UHFFFAOYAT".
- Emedastine iupacName "1".
- Emedastine kegg "D07890".
- Emedastine molecularWeight "302.415".
- Emedastine n "4".
- Emedastine o "1".
- Emedastine pubchem "3219".
- Emedastine smiles "OCCn1cN3CCCNCC3".
- Emedastine stdinchi "1".
- Emedastine stdinchikey "KBUZBQVCBVDWKX-UHFFFAOYSA-N".
- Emedastine tradename "Emadine".
- Emedastine unii "9".
- Emedastine verifiedrevid "461093245".
- Emedastine subject Category:Benzimidazoles.
- Emedastine subject Category:Diazepanes.
- Emedastine subject Category:Ethers.
- Emedastine subject Category:H1_receptor_antagonists.
- Emedastine type Adversary109773245.
- Emedastine type CausalAgent100007347.
- Emedastine type H1ReceptorAntagonists.
- Emedastine type LivingThing100004258.
- Emedastine type Object100002684.
- Emedastine type Organism100004475.
- Emedastine type Person100007846.
- Emedastine type PhysicalEntity100001930.
- Emedastine type Whole100003553.
- Emedastine type YagoLegalActor.
- Emedastine type YagoLegalActorGeo.
- Emedastine type Drug.
- Emedastine type DrugProduct.
- Emedastine type FunctionalSubstance.
- Emedastine comment "Emedastine (trade name Emadine) is a second generation[citation needed] antihistamine used in eye drops to treat allergic conjunctivitis. It acts as a H1 receptor antagonist. It works by blocking certain natural substances, histamines that cause allergic symptoms. It is used in form of the difumarate. The formation of emedastine difumarate is a white, crystalline, water-soluble fine powder. Emedasine is applied as an eye drop with 2 times a day.".
- Emedastine label "Emedastine".
- Emedastine label "Emedastyna".
- Emedastine sameAs Emedastyna.
- Emedastine sameAs m.0cnb3k.
- Emedastine sameAs Q5370305.
- Emedastine sameAs Q5370305.
- Emedastine sameAs emedastine.
- Emedastine sameAs DB01084.
- Emedastine sameAs 3219.
- Emedastine sameAs Emedastine.
- Emedastine wasDerivedFrom Emedastine?oldid=585939637.
- Emedastine depiction Emedastine.png.
- Emedastine isPrimaryTopicOf Emedastine.