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- Enediyne abstract "Enediynes are a class of bacterial natural products characterized by either nine- and ten-membered rings containing two triple bonds separated by a double bond. Many of these compounds are capable of undergoing Bergman cyclization. The resulting diradical, a 1,4-dehydrobenzene derivative, is capable of abstracting hydrogen atoms from the sugar backbone of DNA which results in strand scission. This high reactivity with DNA makes the substances toxic. They are being researched as antitumor agents. Several of the naturally occurring enediynes have entered clinical trials against cancer and in Japan neocarzinostatin is used clinically.Three classes of enediynes exist: Calicheamicin/esperamicin Dynemicin Chromoprotein typesThe enediyne group in those compounds is often called a warhead.".
- Enediyne thumbnail Calicheamicin.png?width=300.
- Enediyne wikiPageID "21032939".
- Enediyne wikiPageRevisionID "542859992".
- Enediyne hasPhotoCollection Enediyne.
- Enediyne subject Category:Antibiotics.
- Enediyne subject Category:Cancer_research.
- Enediyne subject Category:Enediynes.
- Enediyne subject Category:Functional_groups.
- Enediyne type Abstraction100002137.
- Enediyne type FunctionalGroups.
- Enediyne type Group100031264.
- Enediyne comment "Enediynes are a class of bacterial natural products characterized by either nine- and ten-membered rings containing two triple bonds separated by a double bond. Many of these compounds are capable of undergoing Bergman cyclization. The resulting diradical, a 1,4-dehydrobenzene derivative, is capable of abstracting hydrogen atoms from the sugar backbone of DNA which results in strand scission. This high reactivity with DNA makes the substances toxic.".
- Enediyne label "Eendiyn".
- Enediyne label "Endiine".
- Enediyne label "Enediyne".
- Enediyne label "エンジイン".
- Enediyne label "烯二炔".
- Enediyne sameAs Endiine.
- Enediyne sameAs エンジイン.
- Enediyne sameAs Eendiyn.
- Enediyne sameAs m.05b2xmp.
- Enediyne sameAs Q408335.
- Enediyne sameAs Q408335.
- Enediyne sameAs Enediyne.
- Enediyne wasDerivedFrom Enediyne?oldid=542859992.
- Enediyne depiction Calicheamicin.png.
- Enediyne isPrimaryTopicOf Enediyne.