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• Enzyme_kinetics abstract "Enzyme kinetics is the study of the chemical reactions that are catalysed by enzymes. In enzyme kinetics, the reaction rate is measured and the effects of varying the conditions of the reaction is investigated. Studying an enzyme's kinetics in this way can reveal the catalytic mechanism of this enzyme, its role in metabolism, how its activity is controlled, and how a drug or an agonist might inhibit the enzyme.Enzymes are usually protein molecules that manipulate other molecules — the enzymes' substrates. These target molecules bind to an enzyme's active site and are transformed into products through a series of steps known as the enzymatic mechanism. These mechanisms can be divided into single-substrate and multiple-substrate mechanisms. Kinetic studies on enzymes that only bind one substrate, such as triosephosphate isomerase, aim to measure the affinity with which the enzyme binds this substrate and the turnover rate. Some other examples of enzymes are phosphofructokinase and hexokinase, both of which are important for cellular respiration (glycolysis).When enzymes bind multiple substrates, such as dihydrofolate reductase (shown right), enzyme kinetics can also show the sequence in which these substrates bind and the sequence in which products are released. An example of enzymes that bind a single substrate and release multiple products are proteases, which cleave one protein substrate into two polypeptide products. Others join two substrates together, such as DNA polymerase linking a nucleotide to DNA. Although these mechanisms are often a complex series of steps, there is typically one rate-determining step that determines the overall kinetics. This rate-determining step may be a chemical reaction or a conformational change of the enzyme or substrates, such as those involved in the release of product(s) from the enzyme.Knowledge of the enzyme's structure is helpful in interpreting kinetic data. For example, the structure can suggest how substrates and products bind during catalysis; what changes occur during the reaction; and even the role of particular amino acid residues in the mechanism. Some enzymes change shape significantly during the mechanism; in such cases, it is helpful to determine the enzyme structure with and without bound substrate analogues that do not undergo the enzymatic reaction.Not all biological catalysts are protein enzymes; RNA-based catalysts such as ribozymes and ribosomes are essential to many cellular functions, such as RNA splicing and translation. The main difference between ribozymes and enzymes is that RNA catalysts are composed of nucleotides, whereas enzymes are composed of amino acids. Ribozymes also perform a more limited set of reactions, although their reaction mechanisms and kinetics can be analysed and classified by the same methods.".
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• Enzyme_kinetics wikiPageExternalLink EzCatDB.
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• Enzyme_kinetics wikiPageExternalLink kinetics.
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• Enzyme_kinetics wikiPageID "3043886".
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• Enzyme_kinetics hasPhotoCollection Enzyme_kinetics.
• Enzyme_kinetics subject Category:Catalysis.
• Enzyme_kinetics subject Category:Enzyme_kinetics.
• Enzyme_kinetics type Abstraction100002137.
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• Enzyme_kinetics type Enzymes.
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• Enzyme_kinetics comment "Enzyme kinetics is the study of the chemical reactions that are catalysed by enzymes. In enzyme kinetics, the reaction rate is measured and the effects of varying the conditions of the reaction is investigated.".
• Enzyme_kinetics label "Cinética enzimática".
• Enzyme_kinetics label "Cinética enzimática".
• Enzyme_kinetics label "Cinétique enzymatique".
• Enzyme_kinetics label "Enzyme kinetics".
• Enzyme_kinetics label "Enzymkinetik".
• Enzyme_kinetics label "حركيات الإنزيم".
• Enzyme_kinetics label "酵素反応速度論".
• Enzyme_kinetics label "酶动力学".
• Enzyme_kinetics sameAs Enzymkinetik.
• Enzyme_kinetics sameAs Cinética_enzimática.
• Enzyme_kinetics sameAs Entzimen_zinetika.
• Enzyme_kinetics sameAs Cinétique_enzymatique.
• Enzyme_kinetics sameAs 酵素反応速度論.
• Enzyme_kinetics sameAs Kinetyka_enzymatyczna.
• Enzyme_kinetics sameAs Cinética_enzimática.
• Enzyme_kinetics sameAs m.08ms44.
• Enzyme_kinetics sameAs Q883112.
• Enzyme_kinetics sameAs Q883112.
• Enzyme_kinetics sameAs Enzyme_kinetics.
• Enzyme_kinetics wasDerivedFrom Enzyme_kinetics?oldid=599351672.
• Enzyme_kinetics depiction EcDHFR_raytraced.png.
• Enzyme_kinetics isPrimaryTopicOf Enzyme_kinetics.