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- Epothilone abstract "The epothilones are a new class of cancer drugs. Like taxanes, they prevent cancer cells from dividing by interfering with tubulin, but in early trials epithilones have better efficacy and milder adverse effects than taxanes.As of September 2008, epothilones A to F have been identified and characterised.Early studies in cancer cell lines and in human cancer patients indicate superior efficacy to the taxanes. Their mechanism of action is similar, but their chemical structure is simpler. Due to their better water solubility, cremophors (solubilizing agents used for paclitaxel which can affect cardiac function and cause severe hypersensitivity) are not needed. Endotoxin-like properties known from paclitaxel, like activation of macrophages synthesizing inflammatory cytokines and nitric oxide, are not observed for epothilone B.Epothilones were originally identified as metabolites produced by the soil-dwelling myxobacterium Sorangium cellulosum.".
- Epothilone thumbnail Epothilone_A_B.svg?width=300.
- Epothilone wikiPageID "5139511".
- Epothilone wikiPageRevisionID "603013756".
- Epothilone hasPhotoCollection Epothilone.
- Epothilone subject Category:Epoxides.
- Epothilone subject Category:Lactams.
- Epothilone subject Category:Mitotic_inhibitors.
- Epothilone subject Category:Thiazoles.
- Epothilone subject Category:Total_synthesis.
- Epothilone type Inhibitor114724436.
- Epothilone type Matter100020827.
- Epothilone type MitoticInhibitors.
- Epothilone type PhysicalEntity100001930.
- Epothilone type Substance100020090.
- Epothilone comment "The epothilones are a new class of cancer drugs. Like taxanes, they prevent cancer cells from dividing by interfering with tubulin, but in early trials epithilones have better efficacy and milder adverse effects than taxanes.As of September 2008, epothilones A to F have been identified and characterised.Early studies in cancer cell lines and in human cancer patients indicate superior efficacy to the taxanes. Their mechanism of action is similar, but their chemical structure is simpler.".
- Epothilone label "Epothilone".
- Epothilone label "Epothilone".
- Epothilone label "Épothilone".
- Epothilone label "エポチロン".
- Epothilone sameAs Epothilone.
- Epothilone sameAs Épothilone.
- Epothilone sameAs エポチロン.
- Epothilone sameAs m.0d4kz2.
- Epothilone sameAs Q408201.
- Epothilone sameAs Q408201.
- Epothilone sameAs Epothilone.
- Epothilone wasDerivedFrom Epothilone?oldid=603013756.
- Epothilone depiction Epothilone_A_B.svg.
- Epothilone isPrimaryTopicOf Epothilone.
