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- Epsin abstract "Epsins are a family of membrane proteins that are important in creating membrane curvature. Epsins contribute to membrane deformations like endocytosis, and block vesicle formation during mitosis.Epsins have many different domains to interact with various proteins related to endocytosis. At its N-terminus is an ENTH domain that binds phosphatidylinositol (4,5)-bisphosphate, meaning that it binds a lipid of biological membranes. It has also been postulated that this is a site for cargo-binding. In the middle of the epsin sequence are two UIMs (ubiquitin-interacting motifs). The C-terminus contains multiple binding sites, for example for clathrin and AP2 adaptors. As such, epsins are able to bind to membranes with specific cargo and connect them with the endocytosis machinery, so one may understand epsins as something like Swiss army knives for endocytosis.They may be the major membrane curvature-driving proteins in many clathrin-coated vesicle budding events.Epsin 4, which encodes the protein enthoprotin, now known as clathrin interactor 1 (CLINT1), has been shown to be involved in the genetic susceptibility to schizophrenia in four independent studies. A genetic abnormality in CLINT1 is assumed to change the way internalisation of neurotransmitter receptors occurs in the brains of people with schizophrenia. The epsin homologue of C.elegans is EPN-1. EPN-1 conserves the UIM, ENTH domain, and clathrin-binding motif.".
- Epsin wikiPageExternalLink S1357-2725(06)00352-9.
- Epsin wikiPageExternalLink epsin.htm.
- Epsin wikiPageID "6918144".
- Epsin wikiPageRevisionID "591220619".
- Epsin hasPhotoCollection Epsin.
- Epsin subject Category:Peripheral_membrane_proteins.
- Epsin type Abstraction100002137.
- Epsin type Chemical114806838.
- Epsin type Compound114818238.
- Epsin type Macromolecule114944888.
- Epsin type Material114580897.
- Epsin type Matter100020827.
- Epsin type Molecule114682133.
- Epsin type OrganicCompound114727670.
- Epsin type Part113809207.
- Epsin type PeripheralMembraneProteins.
- Epsin type PhysicalEntity100001930.
- Epsin type Protein114728724.
- Epsin type Relation100031921.
- Epsin type Substance100019613.
- Epsin type Thing100002452.
- Epsin type Unit109465459.
- Epsin comment "Epsins are a family of membrane proteins that are important in creating membrane curvature. Epsins contribute to membrane deformations like endocytosis, and block vesicle formation during mitosis.Epsins have many different domains to interact with various proteins related to endocytosis. At its N-terminus is an ENTH domain that binds phosphatidylinositol (4,5)-bisphosphate, meaning that it binds a lipid of biological membranes. It has also been postulated that this is a site for cargo-binding.".
- Epsin label "Epsin".
- Epsin sameAs m.0gw_2k.
- Epsin sameAs Q5383980.
- Epsin sameAs Q5383980.
- Epsin sameAs Epsin.
- Epsin wasDerivedFrom Epsin?oldid=591220619.
- Epsin isPrimaryTopicOf Epsin.