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- Esperamicin abstract "The esperamicins are a class of bacteria-derived chromoprotein enediyne antibiotics, of which esperamicin A1 is the most well studied. Esperamcin A1 and the related enediyne calicheamicin are the two most potent antitumor agents known. The esperamicins are extremely toxic DNA splicing compounds.Oxygen and oxygen scavengers have no significant effect on DNA breakage. The cleavage of DNA by esperamicin is greatly accelerated in the presence of thiol compounds. Oxygen and active oxygen-radical scavengers have no significant influence upon DNA strand breakage by esperamicin. The preferential cutting sites of esperamicin are at thymidylate residues, and the frequency of nucleobase attacked (T greater than C greater than A greater than G) is different from that of calicheamicin (C much greater than T greater than A = G), neocarzinostatin (T greater than A greater than C greater than G), or bleomycin (C greater than T greater than A greater than G).".
- Esperamicin thumbnail Esperamicin.png?width=300.
- Esperamicin wikiPageID "21032802".
- Esperamicin wikiPageRevisionID "565617295".
- Esperamicin hasPhotoCollection Esperamicin.
- Esperamicin imagefile "Esperamicin.png".
- Esperamicin imagesize "200".
- Esperamicin name "Esperamicin A1".
- Esperamicin verifiedfields "changed".
- Esperamicin verifiedrevid "399920724".
- Esperamicin watchedfields "changed".
- Esperamicin subject Category:Antibiotics.
- Esperamicin subject Category:Cancer_research.
- Esperamicin subject Category:Enediynes.
- Esperamicin type Agent114778436.
- Esperamicin type Antibacterial102716205.
- Esperamicin type Antibiotic102716866.
- Esperamicin type Antibiotics.
- Esperamicin type CausalAgent100007347.
- Esperamicin type Drug103247620.
- Esperamicin type Matter100020827.
- Esperamicin type Medicine103740161.
- Esperamicin type PhysicalEntity100001930.
- Esperamicin type Substance100020090.
- Esperamicin type ChemicalCompound.
- Esperamicin type ChemicalSubstance.
- Esperamicin type ChemicalSubstanceType.
- Esperamicin type ChemicalObject.
- Esperamicin type Thing.
- Esperamicin comment "The esperamicins are a class of bacteria-derived chromoprotein enediyne antibiotics, of which esperamicin A1 is the most well studied. Esperamcin A1 and the related enediyne calicheamicin are the two most potent antitumor agents known. The esperamicins are extremely toxic DNA splicing compounds.Oxygen and oxygen scavengers have no significant effect on DNA breakage. The cleavage of DNA by esperamicin is greatly accelerated in the presence of thiol compounds.".
- Esperamicin label "Esperamicin".
- Esperamicin label "エスペラミシン".
- Esperamicin sameAs エスペラミシン.
- Esperamicin sameAs m.05b25fl.
- Esperamicin sameAs Q5398839.
- Esperamicin sameAs Q5398839.
- Esperamicin sameAs Esperamicin.
- Esperamicin wasDerivedFrom Esperamicin?oldid=565617295.
- Esperamicin depiction Esperamicin.png.
- Esperamicin isPrimaryTopicOf Esperamicin.
- Esperamicin name "Esperamicin A1".
