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- Exelixis abstract "Exelixis is a genomics-based drug discovery company located in South San Francisco, Ca., and the producer of Cometriq, a treatment approved by the U.S. Food and Drug Administration (FDA) for medullary thyroid cancer with clinical activity in several other types of metastatic cancer. It works on the development of anti-cancer therapies. Exelixis has several compounds in various stages of FDA approval including : XL147 that targets phosphoinositide-3 kinase (PI3K); and XL765, which targets PI3K and mTOR, kinases in the PI3K signaling pathway. XL880 (foretinib)The company also has various compounds in phase 1 clinical trials, including XL518 or GDC0973, a small molecule inhibitor of the MEK. Co-developed with Roche. XL228, which targets insulin-like growth factor type 1 receptor, an RTK in a range of human tumors; XL139 that targets Hedgehog; XL413, a small molecule inhibitor of the serine-threonine kinase CDC7; XL888, a synthetic inhibitor of HSP90, a chaperone protein that promotes the activity and stability of a range of regulatory proteins, including kinases.Its lead compound, XL184, has been approved for treatment of medullary thyroid cancer and is currently in a number of clinical trials for prostate, ovarian, brain, melanoma, breast, non-small cell lung, hepatocellular, kidney. During its trial for the treatment of medullary thyroid cancer, XL184 was designated orphan drug status by the FDA and given the generic name, cabozantinib. Cabozantinib is an inhibitor of the tyrosine kinases Met and VEGFR2, and has been shown to abrogate tumor growth, metastasis, and angiogenesis.".
- Exelixis foundingYear "1994".
- Exelixis industry Biotechnology.
- Exelixis location South_San_Francisco,_California.
- Exelixis location United_States.
- Exelixis type Public_company.
- Exelixis wikiPageExternalLink www.exelixis.com.
- Exelixis wikiPageExternalLink www.exelixis.com.
- Exelixis wikiPageID "1302007".
- Exelixis wikiPageRevisionID "551777378".
- Exelixis companyLogo "220".
- Exelixis companyName "Exelixis".
- Exelixis companySlogan "A Better Way to Better Medicine".
- Exelixis companyType Public_company.
- Exelixis foundation "1994".
- Exelixis hasPhotoCollection Exelixis.
- Exelixis homepage www.exelixis.com.
- Exelixis industry Biotechnology.
- Exelixis keyPeople "Frank Karbe, CFO".
- Exelixis keyPeople "Gisela M. Schwab, Executive Vice President and Chief Medical Officer".
- Exelixis keyPeople "Lupe M. Rivera, Senior Vice President, Operations".
- Exelixis keyPeople "Michael Morrissey, President, Research and Development".
- Exelixis keyPeople "Pamela A. Simonton, Executive Vice President and General Counsel".
- Exelixis keyPeople "Peter Lamb, Senior Vice President, Discovery Research and Chief Scientific Officer".
- Exelixis location South_San_Francisco,_California.
- Exelixis location United_States.
- Exelixis wordnet_type synset-company-noun-1.
- Exelixis subject Category:Biotechnology_companies_of_the_United_States.
- Exelixis subject Category:Companies_in_the_NASDAQ_Biotechnology_Index.
- Exelixis subject Category:Companies_listed_on_NASDAQ.
- Exelixis type Abstraction100002137.
- Exelixis type BiotechnologyCompanies.
- Exelixis type CompaniesInTheNASDAQBiotechnologyIndex.
- Exelixis type CompaniesListedOnNASDAQ.
- Exelixis type Company108058098.
- Exelixis type Group100031264.
- Exelixis type Institution108053576.
- Exelixis type Organization108008335.
- Exelixis type SocialGroup107950920.
- Exelixis type YagoLegalActor.
- Exelixis type YagoLegalActorGeo.
- Exelixis type YagoPermanentlyLocatedEntity.
- Exelixis type Agent.
- Exelixis type Company.
- Exelixis type Organisation.
- Exelixis type Organization.
- Exelixis type Agent.
- Exelixis type SocialPerson.
- Exelixis type Thing.
- Exelixis comment "Exelixis is a genomics-based drug discovery company located in South San Francisco, Ca., and the producer of Cometriq, a treatment approved by the U.S. Food and Drug Administration (FDA) for medullary thyroid cancer with clinical activity in several other types of metastatic cancer. It works on the development of anti-cancer therapies.".
- Exelixis label "Exelixis".
- Exelixis sameAs m.04r68_.
- Exelixis sameAs Q5419989.
- Exelixis sameAs Q5419989.
- Exelixis sameAs Exelixis.
- Exelixis wasDerivedFrom Exelixis?oldid=551777378.
- Exelixis homepage www.exelixis.com.
- Exelixis isPrimaryTopicOf Exelixis.
- Exelixis name "Exelixis".