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- Exon_junction_complex abstract "The exon junction complex (EJC) has major influences on translation, surveillance and localization of the spliced mRNA. It is first deposited onto mRNA during splicing and is then transported into the cytoplasm. There it plays a major role in post-transcriptional regulation of mRNA. It is believed that exon junction complexes provide a position-specific memory of the splicing event. The EJC consists of a stable heterotetramer core, which serves as a binding platform for other factors necessary for the mRNA pathway. The core of the EJC contains the protein eukaryotic initiation factor 4AIII (eIF4AIII; a DEAD-box RNA helicase) bound to an adenosine triphosphate (ATP) analog, as well as the additional proteins Magoh and Y14. The binding of these proteins to nuclear speckled domains has been measured recently and it may be regulated by PI3K/AKT/mTOR signaling pathways. In order for the binding of the complex to the mRNA to occur, the eIF4AIII factor is inhibited, stopping the hydrolysis of ATP. This recognizes EJC as an ATP dependent complex. EJC also interacts with a large number of additional proteins; most notably SR proteins. These interactions are suggested to be important for mRNA compaction.".
- Exon_junction_complex thumbnail Exon_junction_complex.gif?width=300.
- Exon_junction_complex wikiPageID "22300778".
- Exon_junction_complex wikiPageRevisionID "600364095".
- Exon_junction_complex hasPhotoCollection Exon_junction_complex.
- Exon_junction_complex subject Category:RNA.
- Exon_junction_complex subject Category:Spliceosome.
- Exon_junction_complex comment "The exon junction complex (EJC) has major influences on translation, surveillance and localization of the spliced mRNA. It is first deposited onto mRNA during splicing and is then transported into the cytoplasm. There it plays a major role in post-transcriptional regulation of mRNA. It is believed that exon junction complexes provide a position-specific memory of the splicing event.".
- Exon_junction_complex label "EJC".
- Exon_junction_complex label "Exon junction complex".
- Exon_junction_complex sameAs EJC.
- Exon_junction_complex sameAs m.05sy9cq.
- Exon_junction_complex sameAs Q3717361.
- Exon_junction_complex sameAs Q3717361.
- Exon_junction_complex wasDerivedFrom Exon_junction_complex?oldid=600364095.
- Exon_junction_complex depiction Exon_junction_complex.gif.
- Exon_junction_complex isPrimaryTopicOf Exon_junction_complex.
