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- Expression_quantitative_trait_loci abstract "Expression quantitative trait loci (eQTLs) are genomic loci that regulate expression levels of mRNAs or proteins. Expression traits differ from most other classical complex traits in one important respect—the measured mRNA or protein trait almost always is the product of a single gene with a specific chromosomal location. eQTLs that map to the approximate location of their gene-of-origin are referred to as cis eQTLs. In contrast, those that map far from the location of their gene-of-origin gene, often on different chromosomes, are referred to as trans eQTLs. The first genome-wide mapping studies of gene expression were initiated in the late 1980s and early 1990s by Damerval and de Vienne. They exploited then innovative 2D protein separation methods and introduced the term "protein quantity locus" or PQL (now sometimes pQTL). The advent of high-throughput array-based methods to measure mRNA abundance in the early 2000s catalyzed an impressive number of expression QTL studies in plants and animals, including humans. Some cis eQTLs are detected in many tissue types but the majority of trans eQTLs are tissue-dependent (dynamic). eQTLs may act in cis (locally) or trans (at a distance) to a gene. The abundance of a gene transcript is directly modified by polymorphism in regulatory elements. Consequently, transcript abundance might be considered as a quantitative trait that can be mapped with considerable power. These have been named expression QTLs (eQTLs) The combination of whole-genome genetic association studies andthe measurement of global gene expression allows the systematic identification of eQTLs. By assaying geneexpression and genetic variation simultaneously on a genome-wide basis in a large number of individuals, statistical genetic methods can be used to map the genetic factors that underpin individual differences in quantitative levels of expression of many thousands oftranscripts. Studies have shown that single nucleotide polymorphisms (SNPs) reproducibly associated with complex disorders as well as certain pharmacologic phenotypes are significantly enriched for eQTLs relative to frequency-matched SNPs.".
- Expression_quantitative_trait_loci wikiPageID "25058426".
- Expression_quantitative_trait_loci wikiPageRevisionID "594101663".
- Expression_quantitative_trait_loci hasPhotoCollection Expression_quantitative_trait_loci.
- Expression_quantitative_trait_loci subject Category:Classical_genetics.
- Expression_quantitative_trait_loci subject Category:Genetics.
- Expression_quantitative_trait_loci subject Category:Statistical_genetics.
- Expression_quantitative_trait_loci comment "Expression quantitative trait loci (eQTLs) are genomic loci that regulate expression levels of mRNAs or proteins. Expression traits differ from most other classical complex traits in one important respect—the measured mRNA or protein trait almost always is the product of a single gene with a specific chromosomal location. eQTLs that map to the approximate location of their gene-of-origin are referred to as cis eQTLs.".
- Expression_quantitative_trait_loci label "EQTL".
- Expression_quantitative_trait_loci label "Expression quantitative trait loci".
- Expression_quantitative_trait_loci sameAs EQTL.
- Expression_quantitative_trait_loci sameAs m.09gdcwy.
- Expression_quantitative_trait_loci sameAs Q5421706.
- Expression_quantitative_trait_loci sameAs Q5421706.
- Expression_quantitative_trait_loci wasDerivedFrom Expression_quantitative_trait_loci?oldid=594101663.
- Expression_quantitative_trait_loci isPrimaryTopicOf Expression_quantitative_trait_loci.