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- FBXW7 abstract "F-box/WD repeat-containing protein 7 is a protein that in humans is encoded by the FBXW7 gene.This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian, breast and colorectal cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Three transcript variants encoding three different isoforms have been found for this gene.".
- FBXW7 entrezgene "55294".
- FBXW7 wikiPageID "14754544".
- FBXW7 wikiPageRevisionID "603898740".
- FBXW7 hasPhotoCollection FBXW7.
- FBXW7 requireManualInspection "no".
- FBXW7 summaryText "This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs , which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian, breast and colorectal cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Three transcript variants encoding three different isoforms have been found for this gene.".
- FBXW7 updateCitations "yes".
- FBXW7 updatePage "yes".
- FBXW7 updateProteinBox "yes".
- FBXW7 updateSummary "yes".
- FBXW7 type Biomolecule.
- FBXW7 type Protein.
- FBXW7 type BiologicalObject.
- FBXW7 comment "F-box/WD repeat-containing protein 7 is a protein that in humans is encoded by the FBXW7 gene.This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.".
- FBXW7 label "FBXW7".
- FBXW7 sameAs m.03gwr9k.
- FBXW7 sameAs Q5424685.
- FBXW7 sameAs Q5424685.
- FBXW7 wasDerivedFrom FBXW7?oldid=603898740.
- FBXW7 isPrimaryTopicOf FBXW7.