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- FMRFamide abstract "FMRFamide (Phe-Met-Arg-Phe) is a neuropeptide from a broad family of FMRFamide-related peptides (FaRPs) all sharing an -RFamide sequence at their C-terminus. First identified in Hard clam Mercenaria mercenaria it is thought to play an important role in cardiac activity regulation. Several FMRFamid related peptides are known, regulating various cellular functions and possessing pharmacological actions, such as anti-opiate effects. In Mercenaria mercenaria, FMRFamide has been isolated and demonstrated to increase both the force and frequency of the heartbeat through a biochemical pathway that is thought to involve the increase of cytoplasmic cAMP in the ventricular region (Higgins et al., 1978).FMRFamide is an important neuropeptide in several phyla such as Insecta, Nematoda, Mollusca and Annelida. It is the most abundant neuropeptide in endocrine cells of insect alimentary tracts along with allatostatin and tachykinin families, however the neuropeptide’s function is not known. Generally, the neuropeptide is encoded by several genes such as flp-1 through flp-22 in C. elegans. The common precursor of the FaRPs is modified to yield many different neuropeptides all having the same FMRFamide sequence. Moreover, these peptides are not functionally redundant.In invertebrates, the FMFRamide-related peptides are known to affect heart rate, blood pressure, gut motility, feeding behaviour and reproduction. In vertebrates such as mice, they are known to affect opioid receptors resulting in elicitation of naloxone-sensitive antinociception and reduction of morphine-induced antinociception.".
- FMRFamide wikiPageExternalLink antinociception.
- FMRFamide wikiPageExternalLink index.html?datasheet=10352&t0=1587883-12317545.
- FMRFamide wikiPageID "2258610".
- FMRFamide wikiPageRevisionID "591338471".
- FMRFamide hasPhotoCollection FMRFamide.
- FMRFamide subject Category:Biomolecules.
- FMRFamide subject Category:Neurotransmitters.
- FMRFamide type Abstraction100002137.
- FMRFamide type Chemical114806838.
- FMRFamide type Compound114818238.
- FMRFamide type Material114580897.
- FMRFamide type Matter100020827.
- FMRFamide type Neurochemical114807410.
- FMRFamide type Neurotransmitter114807558.
- FMRFamide type Neurotransmitters.
- FMRFamide type OrganicCompound114727670.
- FMRFamide type Part113809207.
- FMRFamide type PhysicalEntity100001930.
- FMRFamide type Relation100031921.
- FMRFamide type Substance100019613.
- FMRFamide comment "FMRFamide (Phe-Met-Arg-Phe) is a neuropeptide from a broad family of FMRFamide-related peptides (FaRPs) all sharing an -RFamide sequence at their C-terminus. First identified in Hard clam Mercenaria mercenaria it is thought to play an important role in cardiac activity regulation. Several FMRFamid related peptides are known, regulating various cellular functions and possessing pharmacological actions, such as anti-opiate effects.".
- FMRFamide label "FMRFamide".
- FMRFamide sameAs m.06zw63.
- FMRFamide sameAs Q5426656.
- FMRFamide sameAs Q5426656.
- FMRFamide sameAs FMRFamide.
- FMRFamide wasDerivedFrom FMRFamide?oldid=591338471.
- FMRFamide isPrimaryTopicOf FMRFamide.