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- FOXP2 abstract "Forkhead box protein P2 also known as FOXP2 is a protein that in humans is encoded by the FOXP2 gene, located on human chromosome 7 (7q31, at the SPCH1 locus). FOXP2 orthologs have also been identified in all mammals for which complete genome data are available. The FOXP2 protein contains a forkhead-box DNA-binding domain, making it a member of the FOX group of transcription factors, involved in regulation of gene expression. In addition to this characteristic forkhead-box domain, the protein contains a polyglutamine tract, a zinc finger and a leucine zipper.In humans, mutations of FOXP2 cause a severe speech and language disorder. Versions of FOXP2 exist in similar forms in distantly related vertebrates; functional studies of the gene in mice and in songbirds indicate that it is important for modulating plasticity of neural circuits. Outside the brain FOXP2 has also been implicated in development of other tissues such as the lung and gut. FOXP2 directly regulates a large number of downstream target genes.One particular target that is directly downregulated by FOXP2 in human neurons is the CNTNAP2 gene, a member of the neurexin family; variants in this target gene have been associated with common forms of language impairment. Two amino-acid substitutions distinguish the human FOXP2 protein from that found in chimpanzees, but only one of these two changes is unique to humans. Evidence from genetically manipulated mice and human neuronal cell models suggests that these changes affect the neural functions of FOXP2.".
- FOXP2 entrezgene "93986".
- FOXP2 thumbnail Foxp2,_ISH,_E13.5_mouse,_cerebellum-hindbrain.jpg?width=300.
- FOXP2 wikiPageExternalLink 100092348.html?ispopup=true.
- FOXP2 wikiPageExternalLink 08-the-brain-language-fossils-buried-in-your-cells.
- FOXP2 wikiPageExternalLink doc_wtd020797.html.
- FOXP2 wikiPageExternalLink revisiting-foxp2-and-the-origins-of-language.
- FOXP2 wikiPageExternalLink FOXP2_language.htm.
- FOXP2 wikiPageExternalLink language-and-genetics.
- FOXP2 wikiPageID "184421".
- FOXP2 wikiPageRevisionID "598664609".
- FOXP2 hasPhotoCollection FOXP2.
- FOXP2 subject Category:Evolution_of_language.
- FOXP2 subject Category:Forkhead_transcription_factors.
- FOXP2 subject Category:Human_genes.
- FOXP2 type Biomolecule.
- FOXP2 type Protein.
- FOXP2 type BiologicalObject.
- FOXP2 comment "Forkhead box protein P2 also known as FOXP2 is a protein that in humans is encoded by the FOXP2 gene, located on human chromosome 7 (7q31, at the SPCH1 locus). FOXP2 orthologs have also been identified in all mammals for which complete genome data are available. The FOXP2 protein contains a forkhead-box DNA-binding domain, making it a member of the FOX group of transcription factors, involved in regulation of gene expression.".
- FOXP2 label "FOXP2".
- FOXP2 label "FOXP2".
- FOXP2 label "FOXP2".
- FOXP2 label "FOXP2".
- FOXP2 label "FOXP2".
- FOXP2 label "FOXP2".
- FOXP2 label "Forkhead box P2".
- FOXP2 label "Forkhead-Box-Protein P2".
- FOXP2 label "FoxP2".
- FOXP2 label "Protéine Forkhead-P2".
- FOXP2 sameAs Forkhead-Box-Protein_P2.
- FOXP2 sameAs FoxP2.
- FOXP2 sameAs Protéine_Forkhead-P2.
- FOXP2 sameAs Forkhead_box_P2.
- FOXP2 sameAs FOXP2.
- FOXP2 sameAs FOXP2.
- FOXP2 sameAs FOXP2.
- FOXP2 sameAs m.019614.
- FOXP2 sameAs Q227241.
- FOXP2 sameAs Q227241.
- FOXP2 sameAs FOXP2.
- FOXP2 wasDerivedFrom FOXP2?oldid=598664609.
- FOXP2 depiction Foxp2,_ISH,_E13.5_mouse,_cerebellum-hindbrain.jpg.
- FOXP2 isPrimaryTopicOf FOXP2.
