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- FZD4 abstract "Frizzled-4 is a protein that in humans is encoded by the FZD4 gene. FZD4 has also been designated as CD344 (cluster of differentiation 344).This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Frizzled-4 is the only representative of frizzled family members that binds strongly an additional ligand Norrin that is functionally similar but structurally different from Wingless type proteins. FZD4 signaling induced by Norrin regulates vascular development of vertebrate retina and controls important blood vessels in the ear. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.".
- FZD4 entrezgene "8322".
- FZD4 wikiPageExternalLink ReceptorDisplayForward?receptorID=3062.
- FZD4 wikiPageExternalLink NBK1147.
- FZD4 wikiPageID "14581710".
- FZD4 wikiPageRevisionID "591382238".
- FZD4 hasPhotoCollection FZD4.
- FZD4 requireManualInspection "no".
- FZD4 summaryText "This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Frizzled-4 is the only representative of frizzled family members that binds strongly an additional ligand Norrin that is functionally similar but structurally different from Wingless type proteins. FZD4 signaling induced by Norrin regulates vascular development of vertebrate retina and controls important blood vessels in the ear. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.".
- FZD4 updateCitations "yes".
- FZD4 updatePage "yes".
- FZD4 updateProteinBox "yes".
- FZD4 updateSummary "yes".
- FZD4 subject Category:Clusters_of_differentiation.
- FZD4 subject Category:G_protein_coupled_receptors.
- FZD4 type Biomolecule.
- FZD4 type Protein.
- FZD4 type BiologicalObject.
- FZD4 comment "Frizzled-4 is a protein that in humans is encoded by the FZD4 gene. FZD4 has also been designated as CD344 (cluster of differentiation 344).This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins.".
- FZD4 label "FZD4".
- FZD4 sameAs FZD4.
- FZD4 sameAs m.03d8lc6.
- FZD4 sameAs Q5427443.
- FZD4 sameAs Q5427443.
- FZD4 sameAs FZD4.
- FZD4 wasDerivedFrom FZD4?oldid=591382238.
- FZD4 isPrimaryTopicOf FZD4.