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- Flap_structure-specific_endonuclease_1 abstract "Flap endonuclease 1 is an enzyme that in humans is encoded by the FEN1 gene.The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.".
- Flap_structure-specific_endonuclease_1 entrezgene "2237".
- Flap_structure-specific_endonuclease_1 wikiPageID "14698522".
- Flap_structure-specific_endonuclease_1 wikiPageRevisionID "603877305".
- Flap_structure-specific_endonuclease_1 hasPhotoCollection Flap_structure-specific_endonuclease_1.
- Flap_structure-specific_endonuclease_1 requireManualInspection "no".
- Flap_structure-specific_endonuclease_1 summaryText "The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.".
- Flap_structure-specific_endonuclease_1 updateCitations "yes".
- Flap_structure-specific_endonuclease_1 updatePage "yes".
- Flap_structure-specific_endonuclease_1 updateProteinBox "yes".
- Flap_structure-specific_endonuclease_1 updateSummary "yes".
- Flap_structure-specific_endonuclease_1 type Biomolecule.
- Flap_structure-specific_endonuclease_1 type Protein.
- Flap_structure-specific_endonuclease_1 type BiologicalObject.
- Flap_structure-specific_endonuclease_1 comment "Flap endonuclease 1 is an enzyme that in humans is encoded by the FEN1 gene.The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another.".
- Flap_structure-specific_endonuclease_1 label "FEN1".
- Flap_structure-specific_endonuclease_1 label "Flap structure-specific endonuclease 1".
- Flap_structure-specific_endonuclease_1 sameAs FEN1.
- Flap_structure-specific_endonuclease_1 sameAs m.03gtgns.
- Flap_structure-specific_endonuclease_1 sameAs Q5457450.
- Flap_structure-specific_endonuclease_1 sameAs Q5457450.
- Flap_structure-specific_endonuclease_1 wasDerivedFrom Flap_structure-specific_endonuclease_1?oldid=603877305.
- Flap_structure-specific_endonuclease_1 isPrimaryTopicOf Flap_structure-specific_endonuclease_1.