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- Flux_balance_analysis abstract "Flux balance analysis (FBA) is a mathematical method for simulating metabolism in genome scale reconstructions of metabolic networks. In comparison to traditional methods of modeling, FBA is less intensive in terms of the input data required for constructing the model. Simulations performed using FBA are computationally inexpensive and can calculate steady state metabolic fluxes for large models (over 2000 reactions) in a few seconds on modern personal computers.FBA finds applications in bioprocess engineering to systematically identify modifications to the metabolic networks of microbes used in fermentation processes that improve product yields of industrially important chemicals such as ethanol and succinic acid. It has also been used to identify putative drug targets in cancer and pathogens, rational design of culture media, and more recently host–pathogen interactions have been studied using FBA. The results of FBA can be visualized using flux maps like the image on the right which illustrates the steady state fluxes carried by reactions in glycolysis. The thickness of the arrows is proportional to the flux through the reaction.FBA formalizes the system of equations describing a metabolic network as the dot product of a matrix of the stoichiometric coefficients (the S matrix) and v the vector of the unsolved fluxes. The right hand side of the dot product is a vector of zeros representing the system at steady state. Linear programming is then used to calculate a solution of fluxes corresponding to the steady state.".
- Flux_balance_analysis thumbnail Results_of_FBA.png?width=300.
- Flux_balance_analysis wikiPageExternalLink ptools.
- Flux_balance_analysis wikiPageID "4101904".
- Flux_balance_analysis wikiPageRevisionID "604312007".
- Flux_balance_analysis hasPhotoCollection Flux_balance_analysis.
- Flux_balance_analysis subject Category:Bioinformatics.
- Flux_balance_analysis subject Category:Computational_biology.
- Flux_balance_analysis subject Category:Systems_biology.
- Flux_balance_analysis comment "Flux balance analysis (FBA) is a mathematical method for simulating metabolism in genome scale reconstructions of metabolic networks. In comparison to traditional methods of modeling, FBA is less intensive in terms of the input data required for constructing the model.".
- Flux_balance_analysis label "Análisis de balance de flujo".
- Flux_balance_analysis label "Flux balance analysis".
- Flux_balance_analysis sameAs Análisis_de_balance_de_flujo.
- Flux_balance_analysis sameAs 대사유체.
- Flux_balance_analysis sameAs m.0bj1gc.
- Flux_balance_analysis sameAs Q5463029.
- Flux_balance_analysis sameAs Q5463029.
- Flux_balance_analysis wasDerivedFrom Flux_balance_analysis?oldid=604312007.
- Flux_balance_analysis depiction Results_of_FBA.png.
- Flux_balance_analysis isPrimaryTopicOf Flux_balance_analysis.