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- Fostamatinib abstract "Fostamatinib is an experimental drug candidate for the treatment of a variety of diseases, originally developed by Rigel Pharmaceuticals. The drug is administered orally as a disodium salt, and is a prodrug of the active compound tamatinib (R-406), which is an inhibitor of the enzyme spleen tyrosine kinase (Syk).Fostamatinib has been in phase II trials for rheumatoid arthritis, autoimmune thrombocytopenia and lymphoma.A phase II study of rheumatoid arthritis patients failing to respond to a biologic agent showed little efficacy as compared to placebo, but the drug was well tolerated. In patients with high inflammatory burden, measured by levels of C-reactive protein, ACR20 was achieved by a significantly higher portion of those in the fostamatinib group (42%) versus the placebo group (26%).On June 4, 2013, Astra Zeneca announced they were giving up future development on the compound, and terminated their license with Rigel after early results from a Phase IIb study for rheumatoid arthritis. Astra Zeneca is estimated to lose $140 million as part of the contract termination. Rigel plans to now focus on ITP and start phase III clinical trials soon.".
- Fostamatinib iupacName "[6-({5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate".
- Fostamatinib thumbnail Fostamatinib.svg?width=300.
- Fostamatinib wikiPageExternalLink ITP.
- Fostamatinib wikiPageID "32628812".
- Fostamatinib wikiPageRevisionID "600912749".
- Fostamatinib hasPhotoCollection Fostamatinib.
- Fostamatinib imagecaption "Fostamatinib disodium".
- Fostamatinib imagecaption "Fostamatinib".
- Fostamatinib imagefile "Fostamatinib disodium.svg".
- Fostamatinib imagefile "Fostamatinib.svg".
- Fostamatinib imagesize "200".
- Fostamatinib iupacname "[6--2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate".
- Fostamatinib iupacnameHidden "yes".
- Fostamatinib othernames "Tamatinib fosdium; R-788; NSC-745942; R-935788".
- Fostamatinib subject Category:Organophosphates.
- Fostamatinib subject Category:Prodrugs.
- Fostamatinib subject Category:Pyrimidines.
- Fostamatinib subject Category:Tyrosine_kinase_inhibitors.
- Fostamatinib type Abstraction100002137.
- Fostamatinib type Base114618253.
- Fostamatinib type Chemical114806838.
- Fostamatinib type Compound114818238.
- Fostamatinib type Insecticide114919948.
- Fostamatinib type Material114580897.
- Fostamatinib type Matter100020827.
- Fostamatinib type Organophosphate114969994.
- Fostamatinib type Organophosphates.
- Fostamatinib type Part113809207.
- Fostamatinib type Pesticide114980215.
- Fostamatinib type PhysicalEntity100001930.
- Fostamatinib type Pyrimidine114999913.
- Fostamatinib type Pyrimidines.
- Fostamatinib type Relation100031921.
- Fostamatinib type Substance100019613.
- Fostamatinib type ChemicalCompound.
- Fostamatinib type ChemicalSubstance.
- Fostamatinib type ChemicalObject.
- Fostamatinib type Thing.
- Fostamatinib comment "Fostamatinib is an experimental drug candidate for the treatment of a variety of diseases, originally developed by Rigel Pharmaceuticals.".
- Fostamatinib label "Fostamatinib".
- Fostamatinib sameAs m.0h1gjym.
- Fostamatinib sameAs Q5473550.
- Fostamatinib sameAs Q5473550.
- Fostamatinib sameAs Fostamatinib.
- Fostamatinib wasDerivedFrom Fostamatinib?oldid=600912749.
- Fostamatinib depiction Fostamatinib.svg.
- Fostamatinib isPrimaryTopicOf Fostamatinib.
