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- Frameshift_mutation abstract "A frameshift mutation (also called a framing error or a reading frame shift) is a genetic mutation caused by indels (insertions or deletions) of a number of nucleotides in a DNA sequence that is not divisible by three. Due to the triplet nature of gene expression by codons, the insertion or deletion can change the reading frame (the grouping of the codons), resulting in a completely different translation from the original. The earlier in the sequence the deletion or insertion occurs, the more altered the protein. A frameshift mutation is not the same as a single-nucleotide polymorphism in which a nucleotide is replaced, rather than inserted or deleted. A frameshift mutation will in general cause the reading of the codons after the mutation to code for different amino acids. The frameshift mutation will also alter the first stop codon ("UAA", "UGA" or "UAG") encountered in the sequence. The polypeptide being created could be abnormally short or abnormally long, and will most likely not be functional.Frameshift mutations are apparent in severe genetic diseases such as Tay-Sachs disease and Cystic Fibrosis; they increase susceptibility to certain cancers and classes of familial hypercholesterolaemia; in 1997, a frameshift mutation was linked to resistance to infection by the HIV retrovirus. Frameshift mutations have been proposed as a source of biological novelty, as with the alleged creation of nylonase, however, this interpretation is controversial. A study by Negoro et al (2006) found that a frameshift mutation was unlikely to have been the cause and that rather a two amino acid substitution in the catalytic cleft of an ancestral esterase amplified Ald-hydrolytic activity.".
- Frameshift_mutation thumbnail Frameshift_mutation.jpg?width=300.
- Frameshift_mutation wikiPageExternalLink path.
- Frameshift_mutation wikiPageExternalLink fasta_www.cgi?rm=select&pgm=fy.
- Frameshift_mutation wikiPageExternalLink index.htm.
- Frameshift_mutation wikiPageExternalLink index.php.
- Frameshift_mutation wikiPageExternalLink SNP.
- Frameshift_mutation wikiPageExternalLink apr04.html.
- Frameshift_mutation wikiPageID "610997".
- Frameshift_mutation wikiPageRevisionID "603869208".
- Frameshift_mutation hasPhotoCollection Frameshift_mutation.
- Frameshift_mutation subject Category:Mutation.
- Frameshift_mutation comment "A frameshift mutation (also called a framing error or a reading frame shift) is a genetic mutation caused by indels (insertions or deletions) of a number of nucleotides in a DNA sequence that is not divisible by three. Due to the triplet nature of gene expression by codons, the insertion or deletion can change the reading frame (the grouping of the codons), resulting in a completely different translation from the original.".
- Frameshift_mutation label "Frameshift mutation".
- Frameshift_mutation label "Frameshift".
- Frameshift_mutation label "Frameshiftmutatie".
- Frameshift_mutation label "Mutación con desplazamiento del marco de lectura".
- Frameshift_mutation label "Mutacja przesuwająca ramkę odczytu".
- Frameshift_mutation label "Мутация сдвига рамки считывания".
- Frameshift_mutation label "フレームシフト突然変異".
- Frameshift_mutation sameAs Frameshift.
- Frameshift_mutation sameAs Mutación_con_desplazamiento_del_marco_de_lectura.
- Frameshift_mutation sameAs フレームシフト突然変異.
- Frameshift_mutation sameAs Frameshiftmutatie.
- Frameshift_mutation sameAs Mutacja_przesuwająca_ramkę_odczytu.
- Frameshift_mutation sameAs m.02wb4w.
- Frameshift_mutation sameAs Q1440688.
- Frameshift_mutation sameAs Q1440688.
- Frameshift_mutation wasDerivedFrom Frameshift_mutation?oldid=603869208.
- Frameshift_mutation depiction Frameshift_mutation.jpg.
- Frameshift_mutation isPrimaryTopicOf Frameshift_mutation.
