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- Free-radical_theory_of_aging abstract "The free radical theory of aging (FRTA) states that organisms age because cells accumulate free radical damage over time. A free radical is any atom or molecule that has a single unpaired electron in an outer shell. While a few free radicals such as melanin are not chemically reactive, most biologically-relevant free radicals are highly reactive. For most biological structures, free radical damage is closely associated with oxidative damage. Antioxidants are reducing agents, and limit oxidative damage to biological structures by passivating them from free radicals.Strictly speaking, the free radical theory is only concerned with free radicals such as superoxide ( O2- ), but it has since been expanded to encompass oxidative damage from other reactive oxygen species such as hydrogen peroxide (H2O2), or peroxynitrite (OONO-).Denham Harman first proposed the free radical theory of aging in the 1950s, and in the 1970s extended the idea to implicate mitochondrial production of reactive oxygen species.In some model organisms, such as yeast and Drosophila, there is evidence that reducing oxidative damage can extend lifespan. In mice, interventions that enhance oxidative damage generally shorten lifespan. However, in roundworms (Caenorhabditis elegans), blocking the production of the naturally occurring antioxidant superoxide dismutase has recently been shown to increase lifespan. Whether reducing oxidative damage below normal levels is sufficient to extend lifespan remains an open and controversial question.".
- Free-radical_theory_of_aging thumbnail Free-radicals-oxygen.jpg?width=300.
- Free-radical_theory_of_aging wikiPageExternalLink www.calorierestriction.org.
- Free-radical_theory_of_aging wikiPageExternalLink causes_of_aging.html.
- Free-radical_theory_of_aging wikiPageID "605501".
- Free-radical_theory_of_aging wikiPageRevisionID "582148487".
- Free-radical_theory_of_aging hasPhotoCollection Free-radical_theory_of_aging.
- Free-radical_theory_of_aging subject Category:Ageing.
- Free-radical_theory_of_aging subject Category:Free_radicals.
- Free-radical_theory_of_aging subject Category:Gerontology.
- Free-radical_theory_of_aging subject Category:Proximate_theories_of_biological_aging.
- Free-radical_theory_of_aging subject Category:Theories_of_aging.
- Free-radical_theory_of_aging subject Category:Theories_of_biological_aging.
- Free-radical_theory_of_aging type Abstraction100002137.
- Free-radical_theory_of_aging type Atom114619225.
- Free-radical_theory_of_aging type FreeRadical114874196.
- Free-radical_theory_of_aging type FreeRadicals.
- Free-radical_theory_of_aging type Matter100020827.
- Free-radical_theory_of_aging type Part113809207.
- Free-radical_theory_of_aging type PhysicalEntity100001930.
- Free-radical_theory_of_aging type Relation100031921.
- Free-radical_theory_of_aging type Substance100019613.
- Free-radical_theory_of_aging comment "The free radical theory of aging (FRTA) states that organisms age because cells accumulate free radical damage over time. A free radical is any atom or molecule that has a single unpaired electron in an outer shell. While a few free radicals such as melanin are not chemically reactive, most biologically-relevant free radicals are highly reactive. For most biological structures, free radical damage is closely associated with oxidative damage.".
- Free-radical_theory_of_aging label "Free-radical theory of aging".
- Free-radical_theory_of_aging label "Theorie der freien Radikale".
- Free-radical_theory_of_aging label "Wolnorodnikowa teoria starzenia się".
- Free-radical_theory_of_aging label "Свободнорадикальная теория старения".
- Free-radical_theory_of_aging sameAs Theorie_der_freien_Radikale.
- Free-radical_theory_of_aging sameAs Wolnorodnikowa_teoria_starzenia_się.
- Free-radical_theory_of_aging sameAs m.02vsnd.
- Free-radical_theory_of_aging sameAs Q1129576.
- Free-radical_theory_of_aging sameAs Q1129576.
- Free-radical_theory_of_aging sameAs Free-radical_theory_of_aging.
- Free-radical_theory_of_aging wasDerivedFrom Free-radical_theory_of_aging?oldid=582148487.
- Free-radical_theory_of_aging depiction Free-radicals-oxygen.jpg.
- Free-radical_theory_of_aging isPrimaryTopicOf Free-radical_theory_of_aging.
