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- French_flag_model abstract "The French Flag Model is a conceptual definition of a morphogen, described by Lewis Wolpert in the 1960s. A morphogen is rigorously defined as a signaling molecule that acts directly on cells (not through serial induction) to produce specific cellular responses dependent on morphogen concentration. During early development, morphogen gradients generate different cell types in distinct spatial order.In the French flag model, the French flag is used to represent the effect of a morphogen on cell differentiation: a morphogen affects cell states based on concentration, these states are represented by the different colors of the French flag: high concentrations activate a "blue" gene, lower concentrations activate a "white" gene, with "red" serving as the default state in cells below the necessary concentration threshold.The French Flag model was championed by the leading Drosophila biologist, Peter Lawrence. Christiane Nüsslein-Volhard identified the first morphogen, Bicoid, one of the transcription factors present in a gradient in the Drosophila syncytial embryo. Two labs, that of Gary Struhl and that of Stephen Cohen, then demonstrated that a secreted signaling protein, Decapentaplegic (the Drosophila homologue of Transforming Growth Factor Beta), acted as a morphogen during later stages of Drosophila development. substance governing the pattern of tissue development and, in particular, the positions of the various specialized cell types within a tissue. It spreads from a localized source and forms a concentration gradient across a developing tissue.Well-known morphogens include: Decapentaplegic / Transforming growth factor beta, Hedgehog / Sonic Hedgehog, Wingless / Wnt, Epidermal growth factor, and Fibroblast growth factor.Some of the earliest and best-studied morphogens are transcription factors that diffuse within early Drosophila melanogaster (fruit fly) embryos. However, most morphogens are secreted proteins that signal between cells.Morphogens are defined conceptually, not chemically, so simple chemicals such as retinoic acid may also act as morphogens.".
- French_flag_model thumbnail Concs.gif?width=300.
- French_flag_model wikiPageExternalLink ALifeXIflag.
- French_flag_model wikiPageExternalLink www.flybase.org.
- French_flag_model wikiPageExternalLink 1aahome.htm.
- French_flag_model wikiPageExternalLink query.fcgi?db=OMIM.
- French_flag_model wikiPageExternalLink entrez.
- French_flag_model wikiPageID "14578596".
- French_flag_model wikiPageRevisionID "591373533".
- French_flag_model hasPhotoCollection French_flag_model.
- French_flag_model subject Category:Morphogens.
- French_flag_model comment "The French Flag Model is a conceptual definition of a morphogen, described by Lewis Wolpert in the 1960s. A morphogen is rigorously defined as a signaling molecule that acts directly on cells (not through serial induction) to produce specific cellular responses dependent on morphogen concentration.".
- French_flag_model label "French flag model".
- French_flag_model label "Modèle du drapeau français".
- French_flag_model label "Модель трёхцветного флага".
- French_flag_model sameAs Modèle_du_drapeau_français.
- French_flag_model sameAs m.03d8h3f.
- French_flag_model sameAs Q5502127.
- French_flag_model sameAs Q5502127.
- French_flag_model wasDerivedFrom French_flag_model?oldid=591373533.
- French_flag_model depiction Concs.gif.
- French_flag_model isPrimaryTopicOf French_flag_model.