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- G-CSF_factor_stem-loop_destabilising_element abstract "The G-CSF factor stem-loop destabilising element (SLDE) is an RNA element secreted by fibroblasts and endothelial cells in response to the inflammatory mediators interleukin-1 (IL-1) and tumour necrosis factor-alpha and by activated macrophages. The synthesis of G-CSF is regulated both transcriptionally and through control of mRNA stability. In unstimulated cells G-CSF mRNA is unstable but becomes stabilised in response to IL-1 or tumour necrosis factor alpha, and also in the case of monocytes and macrophages, in response to lipopolysaccharide. It is likely that the presence of the SLDE in the G-CSF mRNA contributes to the specificity of regulation of G-CSF mRNA and enhances the rate of shortening of the poly(A) tail.".
- G-CSF_factor_stem-loop_destabilising_element thumbnail RF00183.jpg?width=300.
- G-CSF_factor_stem-loop_destabilising_element wikiPageID "11420856".
- G-CSF_factor_stem-loop_destabilising_element wikiPageRevisionID "603861829".
- G-CSF_factor_stem-loop_destabilising_element caption "Predicted secondary structure and sequence conservation of G-CSF_SLDE".
- G-CSF_factor_stem-loop_destabilising_element hasPhotoCollection G-CSF_factor_stem-loop_destabilising_element.
- G-CSF_factor_stem-loop_destabilising_element id "RF00183".
- G-CSF_factor_stem-loop_destabilising_element name "G-CSF factor stem-loop destabilising element".
- G-CSF_factor_stem-loop_destabilising_element rfam "RF00183".
- G-CSF_factor_stem-loop_destabilising_element rnaType Cis-regulatory_element.
- G-CSF_factor_stem-loop_destabilising_element symbol "G-CSF_SLDE".
- G-CSF_factor_stem-loop_destabilising_element taxDomain Eukaryote.
- G-CSF_factor_stem-loop_destabilising_element subject Category:Cis-regulatory_RNA_elements.
- G-CSF_factor_stem-loop_destabilising_element type Abstraction100002137.
- G-CSF_factor_stem-loop_destabilising_element type Cis-regulatoryRNAElements.
- G-CSF_factor_stem-loop_destabilising_element type Cognition100023271.
- G-CSF_factor_stem-loop_destabilising_element type Component105868954.
- G-CSF_factor_stem-loop_destabilising_element type Concept105835747.
- G-CSF_factor_stem-loop_destabilising_element type Content105809192.
- G-CSF_factor_stem-loop_destabilising_element type Idea105833840.
- G-CSF_factor_stem-loop_destabilising_element type Part105867413.
- G-CSF_factor_stem-loop_destabilising_element type PsychologicalFeature100023100.
- G-CSF_factor_stem-loop_destabilising_element comment "The G-CSF factor stem-loop destabilising element (SLDE) is an RNA element secreted by fibroblasts and endothelial cells in response to the inflammatory mediators interleukin-1 (IL-1) and tumour necrosis factor-alpha and by activated macrophages. The synthesis of G-CSF is regulated both transcriptionally and through control of mRNA stability.".
- G-CSF_factor_stem-loop_destabilising_element label "G-CSF factor stem-loop destabilising element".
- G-CSF_factor_stem-loop_destabilising_element sameAs m.02rbxyb.
- G-CSF_factor_stem-loop_destabilising_element sameAs Q5511884.
- G-CSF_factor_stem-loop_destabilising_element sameAs Q5511884.
- G-CSF_factor_stem-loop_destabilising_element sameAs G-CSF_factor_stem-loop_destabilising_element.
- G-CSF_factor_stem-loop_destabilising_element wasDerivedFrom G-CSF_factor_stem-loop_destabilising_element?oldid=603861829.
- G-CSF_factor_stem-loop_destabilising_element depiction RF00183.jpg.
- G-CSF_factor_stem-loop_destabilising_element isPrimaryTopicOf G-CSF_factor_stem-loop_destabilising_element.
