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- GAIT_element abstract "The gamma interferon inhibitor of translation element or GAIT element is a cis-acting RNA element located in the 3'-UTR of the ceruloplasmin (Cp) mRNA.The GAIT element forms a stem-loop secondary structure. The GAIT element is involved in selective translational silencing of the Cp transcript. Cp is a multifunctional, copper-containing glycoprotein produced by the liver and secreted into the plasma. As an acute-phase protein, its plasma concentration can double during multiple inflammatory conditions. Plasma Cp has been reported to be an independent risk factor for cardiovascular disease, including atherosclerosis, carotid restenosis after endarterectomy, and myocardial infarction. Translational silencing of Cp, and possibly other transcripts, mediated by the GAIT element may contribute to the resolution of the local inflammatory response following cytokine activation of macrophages.The silencing of Cp requires binding of the IFN-gamma-activated inhibitor of translation (GAIT) inhibitor complex to the GAIT element. The GAIT complex consists of the proteins ribosomal protein L13a, glutamyl-prolyl-tRNA synthetase, NS1-associated protein-1, and glyceraldehyde 3-phosphate dehydrogenase.".
- GAIT_element thumbnail RF00179.jpg?width=300.
- GAIT_element wikiPageID "11420850".
- GAIT_element wikiPageRevisionID "603862056".
- GAIT_element caption "Predicted secondary structure and sequence conservation of GAIT".
- GAIT_element hasPhotoCollection GAIT_element.
- GAIT_element id "RF00179".
- GAIT_element name "GAIT element".
- GAIT_element rfam "RF00179".
- GAIT_element rnaType Cis-regulatory_element.
- GAIT_element symbol "GAIT".
- GAIT_element taxDomain Eukaryote.
- GAIT_element subject Category:Cis-regulatory_RNA_elements.
- GAIT_element type Abstraction100002137.
- GAIT_element type Cis-regulatoryRNAElements.
- GAIT_element type Cognition100023271.
- GAIT_element type Component105868954.
- GAIT_element type Concept105835747.
- GAIT_element type Content105809192.
- GAIT_element type Idea105833840.
- GAIT_element type Part105867413.
- GAIT_element type PsychologicalFeature100023100.
- GAIT_element comment "The gamma interferon inhibitor of translation element or GAIT element is a cis-acting RNA element located in the 3'-UTR of the ceruloplasmin (Cp) mRNA.The GAIT element forms a stem-loop secondary structure. The GAIT element is involved in selective translational silencing of the Cp transcript. Cp is a multifunctional, copper-containing glycoprotein produced by the liver and secreted into the plasma.".
- GAIT_element label "GAIT element".
- GAIT_element sameAs m.02rbxx9.
- GAIT_element sameAs Q5512828.
- GAIT_element sameAs Q5512828.
- GAIT_element sameAs GAIT_element.
- GAIT_element wasDerivedFrom GAIT_element?oldid=603862056.
- GAIT_element depiction RF00179.jpg.
- GAIT_element isPrimaryTopicOf GAIT_element.
