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- GDF5 abstract "Growth/differentiation factor 5 is a protein that in humans is encoded by the GDF5 gene.The protein encoded by this gene is closely related to the bone morphogenetic protein (BMP) family and is a member of the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.Growth differentiation factor 5 (GDF5) is a protein belonging to the transforming growth factor beta superfamily that is expressed in the developing central nervous system, and has a role in skeletal and joint development. It also increases the survival of neurones that respond to the neurotransmitter dopamine, and is a potential therapeutic molecule associated with Parkinson's disease.".
- GDF5 entrezgene "8200".
- GDF5 wikiPageID "10214377".
- GDF5 wikiPageRevisionID "606747768".
- GDF5 hasPhotoCollection GDF5.
- GDF5 requireManualInspection "no".
- GDF5 summaryText "The protein encoded by this gene is closely related to the bone morphogenetic protein family and is a member of the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.".
- GDF5 updateCitations "yes".
- GDF5 updatePage "yes".
- GDF5 updateProteinBox "yes".
- GDF5 updateSummary "yes".
- GDF5 subject Category:Developmental_genes_and_proteins.
- GDF5 subject Category:TGFβ_domain.
- GDF5 type Biomolecule.
- GDF5 type Protein.
- GDF5 type BiologicalObject.
- GDF5 comment "Growth/differentiation factor 5 is a protein that in humans is encoded by the GDF5 gene.The protein encoded by this gene is closely related to the bone morphogenetic protein (BMP) family and is a member of the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues.".
- GDF5 label "GDF5".
- GDF5 sameAs m.02q5f3q.
- GDF5 sameAs Q5513078.
- GDF5 sameAs Q5513078.
- GDF5 sameAs GDF5.
- GDF5 sameAs 4638.
- GDF5 wasDerivedFrom GDF5?oldid=606747768.
- GDF5 isPrimaryTopicOf GDF5.