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- GDI1 abstract "Rab GDP dissociation inhibitor alpha is a protein that in humans is encoded by the GDI1 gene.GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific mental retardation.Rab GTPases cycles between the cytosolic compartment, where it is bound to a protein called GDI (GDP Dissociation Inhibitor), and the membrane, where it interacts with a receptor, a nucleotide exchange factor, a GAP (GTPase Activating Protein) and probably other factors that link it to the appropriate SNARE. GDI is non-specific with respect to the rab it binds. However, the exchanger, receptor and GAP, are rab specific.".
- GDI1 entrezgene "2664".
- GDI1 wikiPageID "14157130".
- GDI1 wikiPageRevisionID "591418885".
- GDI1 hasPhotoCollection GDI1.
- GDI1 requireManualInspection "no".
- GDI1 summaryText "GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific mental retardation.".
- GDI1 updateCitations "yes".
- GDI1 updatePage "yes".
- GDI1 updateProteinBox "yes".
- GDI1 updateSummary "yes".
- GDI1 type Biomolecule.
- GDI1 type Protein.
- GDI1 type BiologicalObject.
- GDI1 comment "Rab GDP dissociation inhibitor alpha is a protein that in humans is encoded by the GDI1 gene.GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs.".
- GDI1 label "GDI1".
- GDI1 sameAs m.03cw9bl.
- GDI1 sameAs Q5513085.
- GDI1 sameAs Q5513085.
- GDI1 sameAs GDI1.
- GDI1 sameAs 3161.
- GDI1 wasDerivedFrom GDI1?oldid=591418885.
- GDI1 isPrimaryTopicOf GDI1.