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- GP1BA abstract "Glycoprotein Ib (platelet), alpha polypeptide (GP1BA) also known as CD42b (Cluster of Differentiation 42b), is a human gene.Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.".
- GP1BA entrezgene "2811".
- GP1BA wikiPageID "14284484".
- GP1BA wikiPageRevisionID "591498312".
- GP1BA hasPhotoCollection GP1BA.
- GP1BA requireManualInspection "no".
- GP1BA summaryText "Glycoprotein Ib is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor . The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.".
- GP1BA updateCitations "yes".
- GP1BA updatePage "yes".
- GP1BA updateProteinBox "yes".
- GP1BA updateSummary "yes".
- GP1BA subject Category:Clusters_of_differentiation.
- GP1BA type Biomolecule.
- GP1BA type Protein.
- GP1BA type BiologicalObject.
- GP1BA comment "Glycoprotein Ib (platelet), alpha polypeptide (GP1BA) also known as CD42b (Cluster of Differentiation 42b), is a human gene.Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF).".
- GP1BA label "GP1BA".
- GP1BA sameAs m.03c_8ys.
- GP1BA sameAs Q5514142.
- GP1BA sameAs Q5514142.
- GP1BA sameAs GP1BA.
- GP1BA sameAs 1563.
- GP1BA wasDerivedFrom GP1BA?oldid=591498312.
- GP1BA isPrimaryTopicOf GP1BA.