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- GPR183 abstract "G-protein coupled receptor 183 also known as Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) is a protein that in humans is encoded by the GPR183 gene.This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of the Burkitt's lymphoma cell line BL41. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes.EBI2 helps B cell homing within a lymph node. EBI2 expression increases during B cell activation, after B cell receptor and CD40 stimulation; its expression decreases during germinal cell development due to BCL6--a transcription factor required in germinal center development. EBI2 must turn on to move B cells to the germinal center from the periphery, and must turn off for B cells to exit the germinal center and re-enter the periphery. EBI2 is a receptor for oxysterols, the most potent activator being 7α,25-dihydroxycholesterol.".
- GPR183 entrezgene "1880".
- GPR183 wikiPageID "14410427".
- GPR183 wikiPageRevisionID "606695354".
- GPR183 hasPhotoCollection GPR183.
- GPR183 requireManualInspection "no".
- GPR183 summaryText "This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of the Burkitt's lymphoma cell line BL41. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. EBI2 helps B cell homing within a lymph node. EBI2 expression increases during B cell activation, after B cell receptor and CD40 stimulation; its expression decreases during germinal cell development due to BCL6--a transcription factor required in germinal center development. EBI2 must turn on to move B cells to the germinal center from the periphery, and must turn off for B cells to exit the germinal center and re-enter the periphery. EBI2 is a receptor for oxysterols, the most potent activator being 7α,25-dihydroxycholesterol.".
- GPR183 updateCitations "yes".
- GPR183 updatePage "yes".
- GPR183 updateProteinBox "yes".
- GPR183 updateSummary "yes".
- GPR183 subject Category:G_protein_coupled_receptors.
- GPR183 type Biomolecule.
- GPR183 type Protein.
- GPR183 type BiologicalObject.
- GPR183 comment "G-protein coupled receptor 183 also known as Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) is a protein that in humans is encoded by the GPR183 gene.This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of the Burkitt's lymphoma cell line BL41. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor.".
- GPR183 label "GPR183".
- GPR183 sameAs m.03d2p4t.
- GPR183 sameAs Q5514245.
- GPR183 sameAs Q5514245.
- GPR183 wasDerivedFrom GPR183?oldid=606695354.
- GPR183 isPrimaryTopicOf GPR183.