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- GTPgammaS abstract "GTPgammaS (GTPγS, guanosine 5'-O-[gamma-thio]triphosphate) is a non-hydrolyzable or slowly hydrolyzable G-protein-activating analog of guanosine triphosphate (GTP). Many GTP binding proteins demonstrate activity when bound to GTP, and are inactivated via the hydrolysis of the phosphodiester bond that links the γ-phosphate to the remainder of the nucleotide, leaving a bound guanosine diphosphate (GDP) and releasing an inorganic phosphate. This usually occurs rapidly, and the GTP binding protein can then only be activated by exchanging the GDP for a new GTP molecule. The substitution of sulfur for one of the oxygens of the γ-phosphate of GTP creates a nucleotide that either cannot be hydrolyzed or is only slowly hydrolyzed. This prevents the GTP binding proteins from being inactivated, and allows the cellular processes that they carry out when active to be more easily studied. The consequences of the constitutive activation of GTP binding proteins include stimulation of phosphoinositide hydrolysis, cyclic AMP accumulation or elimination, and activation of specific proto-oncogenes. The 35S labelled radioligand of the compound, 35SGTPγS, is used in autoradiography and G-protein binding studies.".
- GTPgammaS iupacName "[(2S,3R,4S,5S)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydroxyphosphinothioyl hydrogen phosphate".
- GTPgammaS thumbnail GTPgammaS.png?width=300.
- GTPgammaS wikiPageID "13788752".
- GTPgammaS wikiPageRevisionID "589648585".
- GTPgammaS hasPhotoCollection GTPgammaS.
- GTPgammaS imagefile "GTPgammaS.png".
- GTPgammaS imagesize "300".
- GTPgammaS iupacname "[-5--3,4-dihydroxyoxolan-2-yl]methyl dihydroxyphosphinothioyl hydrogen phosphate".
- GTPgammaS verifiedrevid "425009413".
- GTPgammaS watchedfields "changed".
- GTPgammaS subject Category:Nucleotides.
- GTPgammaS type Abstraction100002137.
- GTPgammaS type Chemical114806838.
- GTPgammaS type Compound114818238.
- GTPgammaS type Ester114850483.
- GTPgammaS type Material114580897.
- GTPgammaS type Matter100020827.
- GTPgammaS type Nucleotide114964590.
- GTPgammaS type Nucleotides.
- GTPgammaS type OrganicCompound114727670.
- GTPgammaS type Part113809207.
- GTPgammaS type PhysicalEntity100001930.
- GTPgammaS type Relation100031921.
- GTPgammaS type Substance100019613.
- GTPgammaS type ChemicalCompound.
- GTPgammaS type ChemicalSubstance.
- GTPgammaS type ChemicalObject.
- GTPgammaS type Thing.
- GTPgammaS comment "GTPgammaS (GTPγS, guanosine 5'-O-[gamma-thio]triphosphate) is a non-hydrolyzable or slowly hydrolyzable G-protein-activating analog of guanosine triphosphate (GTP). Many GTP binding proteins demonstrate activity when bound to GTP, and are inactivated via the hydrolysis of the phosphodiester bond that links the γ-phosphate to the remainder of the nucleotide, leaving a bound guanosine diphosphate (GDP) and releasing an inorganic phosphate.".
- GTPgammaS label "GTPgammaS".
- GTPgammaS label "GTPγS".
- GTPgammaS sameAs GTPγS.
- GTPgammaS sameAs m.03cj9qn.
- GTPgammaS sameAs Q5514740.
- GTPgammaS sameAs Q5514740.
- GTPgammaS sameAs GTPgammaS.
- GTPgammaS wasDerivedFrom GTPgammaS?oldid=589648585.
- GTPgammaS depiction GTPgammaS.png.
- GTPgammaS isPrimaryTopicOf GTPgammaS.
