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- G_protein-coupled_receptor_kinase abstract "G protein-coupled receptor kinases (GRKs, GPCRKs) are a family of protein kinases that regulate the activity of G protein-coupled receptors (GPCRs) by phosphorylating their intracellular domains after their associated G proteins have been released and activated. In other words, these proteins are the mediators of tolerance related to GPCRs via up- and downregulation.The phosphorylated serine and threonine residues act as binding sites for arrestin proteins that prevent the reassociation of the G proteins with their receptors, thereby preventing reactivation of the signaling pathway.GRKs regulate also cellular responses independent of their kinase activity. In particular, G protein-coupled receptor kinase 2 interacts with a diverse repertoire of non-GPCR substrates.GRK1 is involved with Rhodopsin phosphorlylation and deactivation. Defects in GRK1 result in Oguchi disease 2.".
- G_protein-coupled_receptor_kinase ecNumber "2.7.11.16".
- G_protein-coupled_receptor_kinase thumbnail Gprotein-coupled_receptor_kinase.png?width=300.
- G_protein-coupled_receptor_kinase wikiPageExternalLink books?id=jtSqgZXIVt4C&pg=PA186.
- G_protein-coupled_receptor_kinase wikiPageExternalLink books?id=sW2SY9zzydMC&pg=PA149.
- G_protein-coupled_receptor_kinase wikiPageID "5669787".
- G_protein-coupled_receptor_kinase wikiPageRevisionID "594692652".
- G_protein-coupled_receptor_kinase caption "Crystal structure of G protein coupled receptor kinase 1 bound to ATP.".
- G_protein-coupled_receptor_kinase ecNumber "2.7".
- G_protein-coupled_receptor_kinase goCode "4703".
- G_protein-coupled_receptor_kinase hasPhotoCollection G_protein-coupled_receptor_kinase.
- G_protein-coupled_receptor_kinase iubmbEcNumber "2".
- G_protein-coupled_receptor_kinase name "G protein-coupled receptor kinase".
- G_protein-coupled_receptor_kinase subject Category:EC_2.7.11.
- G_protein-coupled_receptor_kinase subject Category:Protein_kinases.
- G_protein-coupled_receptor_kinase type Biomolecule.
- G_protein-coupled_receptor_kinase type Enzyme.
- G_protein-coupled_receptor_kinase type BiologicalObject.
- G_protein-coupled_receptor_kinase comment "G protein-coupled receptor kinases (GRKs, GPCRKs) are a family of protein kinases that regulate the activity of G protein-coupled receptors (GPCRs) by phosphorylating their intracellular domains after their associated G proteins have been released and activated.".
- G_protein-coupled_receptor_kinase label "G protein-coupled receptor kinase".
- G_protein-coupled_receptor_kinase label "GRK-киназы".
- G_protein-coupled_receptor_kinase sameAs m.0dz7yb.
- G_protein-coupled_receptor_kinase sameAs Q4355943.
- G_protein-coupled_receptor_kinase sameAs Q4355943.
- G_protein-coupled_receptor_kinase wasDerivedFrom G_protein-coupled_receptor_kinase?oldid=594692652.
- G_protein-coupled_receptor_kinase depiction Gprotein-coupled_receptor_kinase.png.
- G_protein-coupled_receptor_kinase isPrimaryTopicOf G_protein-coupled_receptor_kinase.
- G_protein-coupled_receptor_kinase name "G protein-coupled receptor kinase".
