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- Gadd7 abstract "gadd7 (growth arrested DNA-damage inducible gene 7) is a non-coding RNA discovered in the ovaries of the chinese hamster (Cricetulus griseus). Homologs have been identified in the closely related Long-tailed Dwarf Hamster (C. longicaudatus). Although the gene for this RNA contains open reading frames, translation studies found no protein product hence gadd7 has been classified as non-coding RNA.gadd7 was previously characterised as a hydrogen peroxide-inducible transcript but has more recently been linked with lipotoxicity - where the accumulation of lipids in non-adipose tissue brings about cell death. gadd7 appears to be a key element in the lipotoxicty pathway, when it is knocked out the resulting mutant is much more resistant to oxidative stress.The proposed mechanism for gadd7's role in lipotoxicity is: The lipid palmitate builds to high concentration within a cell Reactive oxygen species (ROS) are generated This stress induces the expression of gadd7 A feed-forward mechanism occurs ER stress brings about death of the cell↑ 1.0 1.1 1.2 ↑ ↑ 3.0 3.1 ↑".
- Gadd7 thumbnail Gadd7_ss.png?width=300.
- Gadd7 wikiPageExternalLink pmidlookup?view=long&pmid=7923213.
- Gadd7 wikiPageExternalLink journal.pgen.1000459.
- Gadd7 wikiPageExternalLink S0003-9861(96)90340-9.
- Gadd7 wikiPageExternalLink S0014-5793(97)01568-8.
- Gadd7 wikiPageExternalLink pmidlookup?view=long&pmid=16960261.
- Gadd7 wikiPageExternalLink pmidlookup?view=long&pmid=16319173.
- Gadd7 wikiPageID "28128245".
- Gadd7 wikiPageRevisionID "594173874".
- Gadd7 caption "Conserved secondary structure of gadd7 RNA".
- Gadd7 hasPhotoCollection Gadd7.
- Gadd7 id "RF01800".
- Gadd7 name "gadd7".
- Gadd7 name "growth arrested DNA-damage inducible gene 7".
- Gadd7 rfam "RF01800".
- Gadd7 rnaType Gene.
- Gadd7 symbol "gadd7".
- Gadd7 taxDomain "Cricetulus".
- Gadd7 width "300".
- Gadd7 subject Category:Non-coding_RNA.
- Gadd7 comment "gadd7 (growth arrested DNA-damage inducible gene 7) is a non-coding RNA discovered in the ovaries of the chinese hamster (Cricetulus griseus). Homologs have been identified in the closely related Long-tailed Dwarf Hamster (C. longicaudatus).".
- Gadd7 label "Gadd7".
- Gadd7 sameAs m.0cm80dp.
- Gadd7 sameAs Q5516305.
- Gadd7 sameAs Q5516305.
- Gadd7 wasDerivedFrom Gadd7?oldid=594173874.
- Gadd7 depiction Gadd7_ss.png.
- Gadd7 isPrimaryTopicOf Gadd7.
