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- Gaussian_network_model abstract "The Gaussian network model (GNM) is a representation of a biological macromolecule as an elastic mass-and-spring network to study, understand, and characterize mechanical aspects of its long-scale dynamics. The model has a wide range of applications from small proteins such as enzymes composed of a single domain, to large macromolecular assemblies such as a ribosome or a viral capsid.The Gaussian network model is a minimalist, coarse-grained approach to study biological molecules. In the model, proteins are represented by nodes corresponding to alpha carbons of the amino acid residues. Similarly, DNA and RNA structures are represented with one to three nodes for each nucleotide. The model uses the harmonic approximation to model interactions, i.e. the spatial interactions between nodes (amino acids or nucleotides) are modeled with a uniform harmonic spring. This coarse-grained representation makes the calculations computationally inexpensive.At molecular level, many biological phenomena, such as catalytic activity of an enzyme, occur within the range of nano- to millisecond timescales. All atom simulation techniques, such as molecular dynamics, rarely reach microsecond trajectory length, depending on the size of the system and accessible computational resources. Normal mode analysis in the context of GNM or elastic network (EN) models, in general, provides insights on the longer-scale functional behaviors of macromolecules. Here, the model captures native state functional motions of a biomolecule in the cost of atomic detail. The inference obtained from this model is complementary to atomic detail simulation techniques.Another model for protein dynamics based on elastic mass-and-spring networks is the Anisotropic Network Model.".
- Gaussian_network_model thumbnail MassSpringNetwork.jpg?width=300.
- Gaussian_network_model wikiPageExternalLink home.
- Gaussian_network_model wikiPageExternalLink hingeprot.html.
- Gaussian_network_model wikiPageExternalLink index.jsp.
- Gaussian_network_model wikiPageExternalLink enm.lobos.nih.gov.
- Gaussian_network_model wikiPageExternalLink anm.htm.
- Gaussian_network_model wikiPageExternalLink gnm.htm.
- Gaussian_network_model wikiPageExternalLink GNM_Online_Calculation.htm.
- Gaussian_network_model wikiPageExternalLink Index.htm.
- Gaussian_network_model wikiPageExternalLink omega.psi.iastate.edu.
- Gaussian_network_model wikiPageExternalLink anm.
- Gaussian_network_model wikiPageExternalLink elnemo.
- Gaussian_network_model wikiPageExternalLink www.molmovdb.org.
- Gaussian_network_model wikiPageExternalLink www.pdb.org.
- Gaussian_network_model wikiPageExternalLink dnabindprot.
- Gaussian_network_model wikiPageExternalLink ,.
- Gaussian_network_model wikiPageID "11210523".
- Gaussian_network_model wikiPageRevisionID "567602332".
- Gaussian_network_model hasPhotoCollection Gaussian_network_model.
- Gaussian_network_model subject Category:Molecular_modelling.
- Gaussian_network_model comment "The Gaussian network model (GNM) is a representation of a biological macromolecule as an elastic mass-and-spring network to study, understand, and characterize mechanical aspects of its long-scale dynamics. The model has a wide range of applications from small proteins such as enzymes composed of a single domain, to large macromolecular assemblies such as a ribosome or a viral capsid.The Gaussian network model is a minimalist, coarse-grained approach to study biological molecules.".
- Gaussian_network_model label "Gaussian network model".
- Gaussian_network_model label "Gaußsche Vektoren".
- Gaussian_network_model label "高斯网络模型".
- Gaussian_network_model sameAs Gaußsche_Vektoren.
- Gaussian_network_model sameAs m.02r3snv.
- Gaussian_network_model sameAs Q263400.
- Gaussian_network_model sameAs Q263400.
- Gaussian_network_model wasDerivedFrom Gaussian_network_model?oldid=567602332.
- Gaussian_network_model depiction MassSpringNetwork.jpg.
- Gaussian_network_model isPrimaryTopicOf Gaussian_network_model.