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- Gene_therapy abstract "Gene therapy is the use of DNA as a drug to treat disease by delivering therapeutic DNA into a patient's cells. The most common form of gene therapy involves using DNA that encodes a functional, therapeutic gene to replace a mutated gene. Other forms involve directly correcting a mutation, or using DNA that encodes a therapeutic protein drug (rather than a natural human gene) to provide treatment. In gene therapy, DNA that encodes a therapeutic protein is packaged within a "vector", which is used to get the DNA inside cells within the body. Once inside, the DNA becomes expressed by the cell machinery, resulting in the production of therapeutic protein, which in turn treats the patient's disease.Gene therapy was first conceptualized in 1972, with the authors urging caution before commencing gene therapy studies in humans. The first FDA-approved gene therapy experiment in the United States occurred in 1990, when Ashanti DeSilva was treated for ADA-SCID. By January 2014, about 2,000 clinical trials had been conducted or had been approved using a number of techniques for gene therapy.Although early clinical failures led many to dismiss gene therapy as over-hyped, clinical successes since 2006 have bolstered new optimism in the promise of gene therapy. These include successful treatment of patients with the retinal disease Leber's congenital amaurosis, X-linked SCID, ADA-SCID, adrenoleukodystrophy, chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (ALL), multiple myeloma, haemophilia and Parkinson's disease. These clinical successes have led to a renewed interest in gene therapy, with several articles in scientific and popular publications calling for continued investment in the field and between 2013 and April 2014, US companies invested over $600 million in gene therapy.In 2012, Glybera became the first gene therapy treatment to be approved for clinical use in either Europe or the United States after its endorsement by the European Commission.".
- Gene_therapy thumbnail Gene_therapy.jpg?width=300.
- Gene_therapy wikiPageExternalLink NCT01639690?term=lentiviral+thalassemia&rank=1.
- Gene_therapy wikiPageExternalLink index.html.
- Gene_therapy wikiPageExternalLink www.asgt.org.
- Gene_therapy wikiPageExternalLink index.html.
- Gene_therapy wikiPageExternalLink www.esgct.eu.
- Gene_therapy wikiPageExternalLink www.gene-watch.org.
- Gene_therapy wikiPageExternalLink molekylaer_medicin_och_genterapi.
- Gene_therapy wikiPageExternalLink 728656.
- Gene_therapy wikiPageExternalLink fulltxt.php?ICID=15907.
- Gene_therapy wikiPageExternalLink launch-stem-cell-therapy-trial-offers-hope-patients-inherited-blood-disorder.
- Gene_therapy wikiPageExternalLink genetherapy.shtml.
- Gene_therapy wikiPageID "12891".
- Gene_therapy wikiPageRevisionID "606369464".
- Gene_therapy hasPhotoCollection Gene_therapy.
- Gene_therapy subject Category:Applied_genetics.
- Gene_therapy subject Category:Bioethics.
- Gene_therapy subject Category:Biotechnology.
- Gene_therapy subject Category:Emerging_technologies.
- Gene_therapy subject Category:Gene_delivery.
- Gene_therapy subject Category:Life_extension.
- Gene_therapy subject Category:Medical_genetics.
- Gene_therapy subject Category:Medical_research.
- Gene_therapy subject Category:Molecular_biology.
- Gene_therapy type Abstraction100002137.
- Gene_therapy type Act100030358.
- Gene_therapy type Activity100407535.
- Gene_therapy type Application100949134.
- Gene_therapy type EmergingTechnologies.
- Gene_therapy type Event100029378.
- Gene_therapy type Occupation100582388.
- Gene_therapy type Profession100609953.
- Gene_therapy type PsychologicalFeature100023100.
- Gene_therapy type Technology100949619.
- Gene_therapy type Use100947128.
- Gene_therapy type YagoPermanentlyLocatedEntity.
- Gene_therapy comment "Gene therapy is the use of DNA as a drug to treat disease by delivering therapeutic DNA into a patient's cells. The most common form of gene therapy involves using DNA that encodes a functional, therapeutic gene to replace a mutated gene. Other forms involve directly correcting a mutation, or using DNA that encodes a therapeutic protein drug (rather than a natural human gene) to provide treatment.".
- Gene_therapy label "Gene therapy".
- Gene_therapy label "Gentherapie".
- Gene_therapy label "Gentherapie".
- Gene_therapy label "Terapia genica".
- Gene_therapy label "Terapia genowa".
- Gene_therapy label "Terapia genética".
- Gene_therapy label "Terapia génica".
- Gene_therapy label "Thérapie génique".
- Gene_therapy label "Генотерапия".
- Gene_therapy label "علاج جيني".
- Gene_therapy label "基因治療".
- Gene_therapy label "遺伝子治療".
- Gene_therapy sameAs Genová_terapie.
- Gene_therapy sameAs Gentherapie.
- Gene_therapy sameAs Terapia_génica.
- Gene_therapy sameAs Terapia_genetiko.
- Gene_therapy sameAs Thérapie_génique.
- Gene_therapy sameAs Terapi_gen.
- Gene_therapy sameAs Terapia_genica.
- Gene_therapy sameAs 遺伝子治療.
- Gene_therapy sameAs 유전자_치료.
- Gene_therapy sameAs Gentherapie.
- Gene_therapy sameAs Terapia_genowa.
- Gene_therapy sameAs Terapia_genética.
- Gene_therapy sameAs m.03cpd.
- Gene_therapy sameAs Q213901.
- Gene_therapy sameAs Q213901.
- Gene_therapy sameAs Gene_therapy.
- Gene_therapy wasDerivedFrom Gene_therapy?oldid=606369464.
- Gene_therapy depiction Gene_therapy.jpg.
- Gene_therapy isPrimaryTopicOf Gene_therapy.
