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- Genome-wide_association_study abstract "In genetic epidemiology, a genome-wide association study (GWA study, or GWAS), also known as whole genome association study (WGA study, or WGAS), is an examination of many common genetic variants in different individuals to see if any variant is associated with a trait. GWAS typically focus on associations between single-nucleotide polymorphisms (SNPs) and traits like major diseases. Genome-wide data sets are increasingly being used to identify biological pathways and networks underlying complex diseases, and in drug development process.These studies normally compare the DNA of two groups of participants: people with the disease (cases) and similar people without (controls). Each person gives a sample of DNA, from which millions of genetic variants are read using SNP arrays. If one type of the variant (one allele) is more frequent in people with the disease, the SNP is said to be "associated" with the disease. The associated SNPs are then considered to mark a region of the human genome which influences the risk of disease. In contrast to methods which specifically test one or a few genetic regions, the GWA studies investigate the entire genome. The approach is therefore said to be non-candidate-driven in contrast to gene-specific candidate-driven studies. GWA studies identify SNPs and other variants in DNA which are associated with a disease, but cannot on their own specify which genes are causal.The first successful GWA study was published in 2005 and investigated patients with age-related macular degeneration. It found two SNPs which had significantly altered allele frequency when comparing with healthy controls. As of 2011, hundreds or thousands of individuals are tested, over 1,200 human GWA studies have examined over 200 diseases and traits, and almost 4,000 SNP associations have been found. Several GWA studies have received criticism for omitting important quality control steps, rendering the findings invalid, but modern publications address these issues. However, the methodology itself still has opponents.".
- Genome-wide_association_study thumbnail Manhattan_Plot.png?width=300.
- Genome-wide_association_study wikiPageExternalLink plink.
- Genome-wide_association_study wikiPageExternalLink www.1000genomes.org.
- Genome-wide_association_study wikiPageExternalLink 17516714.
- Genome-wide_association_study wikiPageExternalLink how-to-read-a-genome-wide-association-study.php.
- Genome-wide_association_study wikiPageExternalLink www.gwascentral.org.
- Genome-wide_association_study wikiPageExternalLink www.haplotype-reference-consortium.org.
- Genome-wide_association_study wikiPageExternalLink www.hapmap.org.
- Genome-wide_association_study wikiPageExternalLink impact-of-functional-information-on-understanding-variation.
- Genome-wide_association_study wikiPageExternalLink index.html.
- Genome-wide_association_study wikiPageExternalLink 185.html.
- Genome-wide_association_study wikiPageExternalLink impute_v2.html.
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- Genome-wide_association_study hasPhotoCollection Genome-wide_association_study.
- Genome-wide_association_study subject Category:Genetic_epidemiology.
- Genome-wide_association_study subject Category:Genetics.
- Genome-wide_association_study subject Category:Human_genome_projects.
- Genome-wide_association_study type Abstraction100002137.
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- Genome-wide_association_study type Activity100407535.
- Genome-wide_association_study type Event100029378.
- Genome-wide_association_study type HumanGenomeProjects.
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- Genome-wide_association_study comment "In genetic epidemiology, a genome-wide association study (GWA study, or GWAS), also known as whole genome association study (WGA study, or WGAS), is an examination of many common genetic variants in different individuals to see if any variant is associated with a trait. GWAS typically focus on associations between single-nucleotide polymorphisms (SNPs) and traits like major diseases.".
- Genome-wide_association_study label "Estudio de asociación del genoma completo".
- Genome-wide_association_study label "Genome-wide association study".
- Genome-wide_association_study label "Genomweite Assoziationsstudie".
- Genome-wide_association_study label "Studio di associazione genome-wide".
- Genome-wide_association_study label "Étude d'association pangénomique".
- Genome-wide_association_study label "Полногеномный поиск ассоциаций".
- Genome-wide_association_study label "全基因组关联分析".
- Genome-wide_association_study sameAs Genomweite_Assoziationsstudie.
- Genome-wide_association_study sameAs Estudio_de_asociación_del_genoma_completo.
- Genome-wide_association_study sameAs Étude_d'association_pangénomique.
- Genome-wide_association_study sameAs Studio_di_associazione_genome-wide.
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- Genome-wide_association_study sameAs Q1098876.
- Genome-wide_association_study sameAs Q1098876.
- Genome-wide_association_study sameAs Genome-wide_association_study.
- Genome-wide_association_study wasDerivedFrom Genome-wide_association_study?oldid=600891672.
- Genome-wide_association_study depiction Manhattan_Plot.png.
- Genome-wide_association_study isPrimaryTopicOf Genome-wide_association_study.
