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- Genome_instability abstract "Genome instability (also “genetic instability” or “genomic instability”) refers to a high frequency of mutations within the genome of a cellular lineage. These mutations can include changes in nucleic acid sequences, chromosomal rearrangements or aneuploidy. Genome instability is central to carcinogenesis but also is a factor in some neurodegenerative diseases such as amyotrophic lateral sclerosis or the neuromuscular disease myotonic dystrophy.The sources of genome instability have only recently begun to be elucidated. A high frequency of externally caused DNA damage can be one source of genome instability since DNA damages can cause inaccurate translesion synthesis past the damages or errors in repair, leading to mutation. Another source of genome instability may be epigenetic or mutational reductions in expression of DNA repair genes. Because endogenous (metabolically-caused) DNA damage is very frequent, occurring on average more than 60,000 times a day in the genomes of human cells, any reduced DNA repair is likely an important source of genome instability.".
- Genome_instability wikiPageID "32706791".
- Genome_instability wikiPageRevisionID "602533180".
- Genome_instability hasPhotoCollection Genome_instability.
- Genome_instability subject Category:Chromosomes.
- Genome_instability subject Category:Genetics.
- Genome_instability type Body109224911.
- Genome_instability type Chromosome105442131.
- Genome_instability type Chromosomes.
- Genome_instability type NaturalObject100019128.
- Genome_instability type Object100002684.
- Genome_instability type PhysicalEntity100001930.
- Genome_instability type Whole100003553.
- Genome_instability comment "Genome instability (also “genetic instability” or “genomic instability”) refers to a high frequency of mutations within the genome of a cellular lineage. These mutations can include changes in nucleic acid sequences, chromosomal rearrangements or aneuploidy.".
- Genome_instability label "Genome instability".
- Genome_instability label "Inestabilidad genómica".
- Genome_instability sameAs Inestabilidad_genómica.
- Genome_instability sameAs m.0h3nxqv.
- Genome_instability sameAs Q2892636.
- Genome_instability sameAs Q2892636.
- Genome_instability sameAs Genome_instability.
- Genome_instability wasDerivedFrom Genome_instability?oldid=602533180.
- Genome_instability isPrimaryTopicOf Genome_instability.