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- Gla_domain abstract "Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain is a protein domain that contains post-translational modifications ofmany glutamate residues by vitamin K-dependent carboxylation to form γ-carboxyglutamate (Gla). The Gla residues are responsible for the high-affinity binding of calcium ions. The GLA domain is responsible for the high-affinity binding of calcium ions. It starts at the N-terminal extremity of the mature form of proteins and ends with a conserved aromatic residue; a conserved Gla-x(3)-Gla-x-Cys motif is found in the middle of the domain which seems to be important for substrate recognition by the carboxylase.The 3D structures of several Gla domains have been solved. Calcium ions induce conformational changes in the Gla domain and are necessary for the Gla domain to fold properly. A common structural feature of functional Gla domains is the clustering of N-terminal hydrophobic residues into a hydrophobic patch that mediates interaction with the cell surface membrane.".
- Gla_domain symbol "Gla".
- Gla_domain thumbnail 1dan_opm.gif?width=300.
- Gla_domain wikiPageID "14091970".
- Gla_domain wikiPageRevisionID "604784604".
- Gla_domain caption "Anchoring of Coagulation factor VIIa to the membrane through its GLA domain".
- Gla_domain hasPhotoCollection Gla_domain.
- Gla_domain interpro "IPR000294".
- Gla_domain name "GLA Domain".
- Gla_domain opmFamily "97".
- Gla_domain opmProtein "1".
- Gla_domain pdb "A:6-47 A:57-98 B:53-93 A:49-90 :49-90 A:49-90 :79-90 L:45-86 L:45-86 :45-86 :45-86 G:45-84 C:6-46 C:6-46 L:8-48 :52-93 :52-93 :52-93 G:52-91 C:47-75 L:65-106 L:65-106 L:65-106 L:65-106 L:65-106 L:65-106 L:65-106 L:65-106 L:65-106".
- Gla_domain pfam "PF00594".
- Gla_domain prosite "PDOC00011".
- Gla_domain scop "1".
- Gla_domain symbol "Gla".
- Gla_domain width "220".
- Gla_domain subject Category:Peripheral_membrane_proteins.
- Gla_domain subject Category:Protein_domains.
- Gla_domain type Abstraction100002137.
- Gla_domain type Attribute100024264.
- Gla_domain type Chemical114806838.
- Gla_domain type Compound114818238.
- Gla_domain type Environment113934596.
- Gla_domain type Macromolecule114944888.
- Gla_domain type Material114580897.
- Gla_domain type Matter100020827.
- Gla_domain type Molecule114682133.
- Gla_domain type OrganicCompound114727670.
- Gla_domain type Part113809207.
- Gla_domain type PeripheralMembraneProteins.
- Gla_domain type PhysicalEntity100001930.
- Gla_domain type Protein114728724.
- Gla_domain type ProteinDomains.
- Gla_domain type Relation100031921.
- Gla_domain type Situation113927383.
- Gla_domain type Sphere114514039.
- Gla_domain type State100024720.
- Gla_domain type Substance100019613.
- Gla_domain type Thing100002452.
- Gla_domain type Unit109465459.
- Gla_domain type Biomolecule.
- Gla_domain type Protein.
- Gla_domain type BiologicalObject.
- Gla_domain comment "Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain is a protein domain that contains post-translational modifications ofmany glutamate residues by vitamin K-dependent carboxylation to form γ-carboxyglutamate (Gla). The Gla residues are responsible for the high-affinity binding of calcium ions. The GLA domain is responsible for the high-affinity binding of calcium ions.".
- Gla_domain label "Gla domain".
- Gla_domain sameAs m.03gqjdc.
- Gla_domain sameAs Q5566066.
- Gla_domain sameAs Q5566066.
- Gla_domain sameAs Gla_domain.
- Gla_domain wasDerivedFrom Gla_domain?oldid=604784604.
- Gla_domain depiction 1dan_opm.gif.
- Gla_domain isPrimaryTopicOf Gla_domain.
