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- GlnA_RNA_motif abstract "The glnA RNA motif is a conserved RNA structure that was predicted by bioinformatics. It is present in a variety of lineages of cyanobacteria, as well as some phages that infect cyanobacteria. It is also found in DNA extracted from uncultivated bacteria living in the ocean that are presumably species of cyanobacteria.glnA RNAs are found in the presumed 5' untranslated regions of genes encoding multiple classes of protein that are involved in nitrogen metabolism. The most prominent of these protein classes are ammonium transporters, the enzymes glutamine synthetase and glutamate synthase and PII protein, which itself regulates nitrogen metabolism. Further supporting a possible role as a cis-regulatory element in control of nitrogen metabolism, the Prochlorococcus marinus gene designed as PMT1479 was more repressed than another other gene in this organism when it was growth without a sufficient supply of nitrogen.It was demonstrated that glnA RNAs correspond to glutamine-binding riboswitches, i.e., they sense glutamine concentrations in order to measure overall nitrogen availability, and regulate the downstream genes appropriately. The original proposal of a riboswitch function was based on the above evidence that glnA RNAs are cis-regulatory, as well as the moderate structural complexity in the three-stem junction of the glnA RNA motif that is comparable to the structures of other known riboswitches. Some glnA RNAs are located adjacent to other glnA RNAs. These "tandem arrangements" are also exhibited by glycine riboswitches and TPP riboswitches where they allow the cell to turn genes off or on within a smaller change of concentration of the riboswitch ligand. In other words, the response curve of the riboswitch better resembles a digital function. However, such cooperative binding was not observed.A possible structural resemblance was observed between the glnA RNA motif and the Downstream-peptide motif. The most apparent similarity is between the stems labeled "P1" in each motif, but other similarities were observed. It was proposed that both motifs represent riboswitches involved in nitrogen metabolism. The fact that RNAs from both motifs selectively bind glutamine supports this hypothesis, but detailed structural data is not yet available. The glnA motif has an E-loop structure (also called a bulged-G module) within it.".
- GlnA_RNA_motif thumbnail GlnA-RNA.svg?width=300.
- GlnA_RNA_motif wikiPageID "26610270".
- GlnA_RNA_motif wikiPageRevisionID "591472075".
- GlnA_RNA_motif caption "Consensus secondary structure of glnA RNAs".
- GlnA_RNA_motif hasPhotoCollection GlnA_RNA_motif.
- GlnA_RNA_motif id "RF01739".
- GlnA_RNA_motif name "glnA RNA motif".
- GlnA_RNA_motif name "glnA RNA".
- GlnA_RNA_motif rfam "RF01739".
- GlnA_RNA_motif rnaType "Cis-regulatory element".
- GlnA_RNA_motif symbol "glnA RNA".
- GlnA_RNA_motif taxDomain Cyanobacteria.
- GlnA_RNA_motif width "300".
- GlnA_RNA_motif subject Category:Cis-regulatory_RNA_elements.
- GlnA_RNA_motif subject Category:Riboswitch.
- GlnA_RNA_motif type Abstraction100002137.
- GlnA_RNA_motif type Cis-regulatoryRNAElements.
- GlnA_RNA_motif type Cognition100023271.
- GlnA_RNA_motif type Component105868954.
- GlnA_RNA_motif type Concept105835747.
- GlnA_RNA_motif type Content105809192.
- GlnA_RNA_motif type Idea105833840.
- GlnA_RNA_motif type Part105867413.
- GlnA_RNA_motif type PsychologicalFeature100023100.
- GlnA_RNA_motif comment "The glnA RNA motif is a conserved RNA structure that was predicted by bioinformatics. It is present in a variety of lineages of cyanobacteria, as well as some phages that infect cyanobacteria. It is also found in DNA extracted from uncultivated bacteria living in the ocean that are presumably species of cyanobacteria.glnA RNAs are found in the presumed 5' untranslated regions of genes encoding multiple classes of protein that are involved in nitrogen metabolism.".
- GlnA_RNA_motif label "GlnA RNA motif".
- GlnA_RNA_motif sameAs m.0bhbh5w.
- GlnA_RNA_motif sameAs Q17146039.
- GlnA_RNA_motif sameAs Q17146039.
- GlnA_RNA_motif sameAs GlnA_RNA_motif.
- GlnA_RNA_motif wasDerivedFrom GlnA_RNA_motif?oldid=591472075.
- GlnA_RNA_motif depiction GlnA-RNA.svg.
- GlnA_RNA_motif isPrimaryTopicOf GlnA_RNA_motif.
