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- Glutaredoxin abstract "Glutaredoxins are small redox enzymes of approximately one hundred amino-acid residues that use glutathione as a cofactor. Glutaredoxins are oxidized by substrates, and reduced non-enzymatically by glutathione. In contrast to thioredoxins, which are reduced by thioredoxin reductase, no oxidoreductase exists that specifically reduces glutaredoxins. Instead, glutaredoxins are reduced by the oxidation of glutathione. Oxidized glutathione is then regenerated by glutathione reductase. Together these components compose the glutathione system.Like thioredoxin, which functions in a similar way, glutaredoxin possesses an active centre disulfide bond. It exists in either a reduced or an oxidized form where the two cysteine residues are linked in an intramolecular disulfide bond. Glutaredoxins function as electron carriers in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. Moreover, GRX act in antioxidant defence by reducing dehydroascorbate, peroxiredoxins, and methionine sulfoxide reductase. Beside their function in antioxidant defence, bacterial and plant GRX were shown to bind iron-sulfur clusters and to deliver the cluster to enzymes on demand.".
- Glutaredoxin symbol "Glutaredoxin".
- Glutaredoxin thumbnail PDB_1kte_EBI.jpg?width=300.
- Glutaredoxin wikiPageExternalLink 1.20.4.1.
- Glutaredoxin wikiPageID "9642591".
- Glutaredoxin wikiPageRevisionID "579579807".
- Glutaredoxin cdd "cd02066".
- Glutaredoxin hasPhotoCollection Glutaredoxin.
- Glutaredoxin interpro "IPR002109".
- Glutaredoxin name "Glutaredoxin".
- Glutaredoxin opmFamily "139".
- Glutaredoxin opmProtein "32400.0".
- Glutaredoxin pdb "A:17-81 A:250-314 A:69-131 A:69-131 :15-80 A:15-80 :15-80 B:172-230 :4-63 A:4-63 A:4-63 :3-69 :3-69 :3-69 A:3-69 B:2-76 A:2-76 A:2-76 :2-76 A:5-66 A:6-67 A:138-162 :138-162 B:3-61 A:3-61 B:102-152 A:155-181 B:155-181 B:155-181".
- Glutaredoxin pfam "PF00462".
- Glutaredoxin pfamClan "CL0172".
- Glutaredoxin prosite "PDOC00173".
- Glutaredoxin scop "1".
- Glutaredoxin symbol "Glutaredoxin".
- Glutaredoxin subject Category:Antioxidants.
- Glutaredoxin subject Category:EC_1.20.4.
- Glutaredoxin subject Category:Protein_domains.
- Glutaredoxin subject Category:Single-pass_transmembrane_proteins.
- Glutaredoxin type Abstraction100002137.
- Glutaredoxin type Attribute100024264.
- Glutaredoxin type Chemical114806838.
- Glutaredoxin type Compound114818238.
- Glutaredoxin type Environment113934596.
- Glutaredoxin type Macromolecule114944888.
- Glutaredoxin type Material114580897.
- Glutaredoxin type Matter100020827.
- Glutaredoxin type Molecule114682133.
- Glutaredoxin type OrganicCompound114727670.
- Glutaredoxin type Part113809207.
- Glutaredoxin type PhysicalEntity100001930.
- Glutaredoxin type Protein114728724.
- Glutaredoxin type ProteinDomains.
- Glutaredoxin type Relation100031921.
- Glutaredoxin type Single-passTransmembraneProteins.
- Glutaredoxin type Situation113927383.
- Glutaredoxin type Sphere114514039.
- Glutaredoxin type State100024720.
- Glutaredoxin type Substance100019613.
- Glutaredoxin type Thing100002452.
- Glutaredoxin type Unit109465459.
- Glutaredoxin type Biomolecule.
- Glutaredoxin type Protein.
- Glutaredoxin type BiologicalObject.
- Glutaredoxin comment "Glutaredoxins are small redox enzymes of approximately one hundred amino-acid residues that use glutathione as a cofactor. Glutaredoxins are oxidized by substrates, and reduced non-enzymatically by glutathione. In contrast to thioredoxins, which are reduced by thioredoxin reductase, no oxidoreductase exists that specifically reduces glutaredoxins. Instead, glutaredoxins are reduced by the oxidation of glutathione. Oxidized glutathione is then regenerated by glutathione reductase.".
- Glutaredoxin label "Glutaredoxin".
- Glutaredoxin label "Glutarredoxina".
- Glutaredoxin label "谷氧还蛋白".
- Glutaredoxin sameAs Glutarédoxine.
- Glutaredoxin sameAs Glutarredoxina.
- Glutaredoxin sameAs m.02pmw1f.
- Glutaredoxin sameAs Q5572458.
- Glutaredoxin sameAs Q5572458.
- Glutaredoxin sameAs Glutaredoxin.
- Glutaredoxin wasDerivedFrom Glutaredoxin?oldid=579579807.
- Glutaredoxin depiction PDB_1kte_EBI.jpg.
- Glutaredoxin isPrimaryTopicOf Glutaredoxin.