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- Golgi_cell abstract "In neuroscience, Golgi cells are inhibitory interneurons found within the granular layer of the cerebellum. They were first identified as inhibitory by Eccles et al. in 1964.It was also the first example of an inhibitory feed back network, where the inhibitory interneuron was identified anatomically.These cells synapse onto the dendrite of granule cells and unipolar brush cells. They receive excitatory input from mossy fibres, also synapsing on granule cells, and parallel fibers, which are long granule cell axons. Thereby this circuitry allows for feed-forward and feed-back inhibition of granule cells.The main synapse made by these cells is a synapse onto the mossy fibre - granule cell excitatory synapse in a glomerulus. The glomerulus is made up of the mossy fibre terminal, granule cell dendrites, the Golgi terminal and is enclosed by a glial coat. The Golgi cell acts by altering the mossy fibre - granule cell synapse.The Golgi cells use GABA as their transmitter. The basal level of GABA produces a postsynaptic leak conductance by tonically activating alpha 6-containing GABA-A receptors on the granule cell.These high-affinity receptors are located both synaptically and extrasynaptically on the granule cell. The synaptic receptors mediate phasic contraction, duration of around 20-30ms whereas the extrasynapatic receptors mediate tonic inhibition of around 200ms, and are activated by synapse spill over.Additionally the GABA acts on GABA-B receptors which are located presynaptically on the mossy fibre terminal. These inhibit the mossy fibre evoked EPSCs of the granule cell in a temperature and frequency dependent manner. At high mossy firing frequency (10 Hz) there is no effect of GABA acting on presynaptic GABA-B receptors on evoked EPSCs. However, at low (1 Hz) firing the GABA does have an effect on the EPSCs mediated via these presynaptic GABA-B receptors.".
- Golgi_cell thumbnail CerebCircuit.png?width=300.
- Golgi_cell wikiPageExternalLink search.php?q=%22Golgi%20Cell%22&t=data&s=cover&b=0&r=20.
- Golgi_cell wikiPageID "2486212".
- Golgi_cell wikiPageRevisionID "602892815".
- Golgi_cell captionNeuron "BC: Basket cell.".
- Golgi_cell captionNeuron "CF: Climbing fiber.".
- Golgi_cell captionNeuron "DCN: Deep cerebellar nuclei.".
- Golgi_cell captionNeuron "GC: Granule cell.".
- Golgi_cell captionNeuron "GgC: Golgi cell.".
- Golgi_cell captionNeuron "IO: Inferior olive.".
- Golgi_cell captionNeuron "MF: Mossy fiber.".
- Golgi_cell captionNeuron "Microcircuitry of the cerebellum. Excitatory synapses are denoted by and inhibitory synapses by .".
- Golgi_cell captionNeuron "PC: Purkinje cell.".
- Golgi_cell captionNeuron "PF: Parallel fiber.".
- Golgi_cell captionNeuron "SC: Stellate cell.".
- Golgi_cell dorlands "c_18".
- Golgi_cell dorlandsid "12223524".
- Golgi_cell hasPhotoCollection Golgi_cell.
- Golgi_cell imageNeuron "CerebCircuit.png".
- Golgi_cell neurolex "Golgi Cell".
- Golgi_cell neurolexid "nifext_129".
- Golgi_cell neuronName "Golgi cell".
- Golgi_cell wordnet_type synset-human_body-noun-1.
- Golgi_cell subject Category:Cells.
- Golgi_cell subject Category:Central_nervous_system_neurons.
- Golgi_cell subject Category:Cerebellum.
- Golgi_cell type CNSNeurons.
- Golgi_cell type Cell100006484.
- Golgi_cell type LivingThing100004258.
- Golgi_cell type NerveCell105465567.
- Golgi_cell type Object100002684.
- Golgi_cell type PhysicalEntity100001930.
- Golgi_cell type SomaticCell105430628.
- Golgi_cell type Whole100003553.
- Golgi_cell comment "In neuroscience, Golgi cells are inhibitory interneurons found within the granular layer of the cerebellum. They were first identified as inhibitory by Eccles et al. in 1964.It was also the first example of an inhibitory feed back network, where the inhibitory interneuron was identified anatomically.These cells synapse onto the dendrite of granule cells and unipolar brush cells.".
- Golgi_cell label "Golgi cell".
- Golgi_cell sameAs m.07h80k.
- Golgi_cell sameAs Q5580667.
- Golgi_cell sameAs Q5580667.
- Golgi_cell sameAs Golgi_cell.
- Golgi_cell wasDerivedFrom Golgi_cell?oldid=602892815.
- Golgi_cell depiction CerebCircuit.png.
- Golgi_cell isPrimaryTopicOf Golgi_cell.
