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DBpedia 2014

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Granisetron abstract "Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors.Granisetron was developed by chemists working at the British drug company Beecham around 1988 and is available as a generic. It is produced by Roche Laboratories under the trade name Kytril. The drug was approved in the United Kingdom in 1991 and in United States in 1994 by the FDA.A granisetron transdermal patch with the trade name Sancuso was approved by the US FDA on September 12, 2008. Sancuso is manufactured by ProStrakan, Inc., a pharmaceutical company headquartered in Bedminster, NJ, with global headquarters in Scotland.Granisetron is metabolized slowly by the liver, giving it a longer than average half-life. One dose usually lasts 4 to 9 hours and is usually administered once or twice daily. This drug is removed from the body by the liver and kidneys.".
Granisetron atcPrefix "A04".
Granisetron atcSuffix "AA02".
Granisetron bioavailability "60.0".
Granisetron casNumber "109889-09-0".
Granisetron chEBI "5537".
Granisetron drugbank "DB00889".
Granisetron fdaUniiCode "WZG3J2MCOL".
Granisetron iupacName "1-methyl-N-((1R,3r,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)-1H-indazole-3-carboxamide".
Granisetron pubchem "3510".
Granisetron thumbnail Granisetron.svg?width=300.
Granisetron wikiPageExternalLink www.kytril.com.
Granisetron wikiPageExternalLink www.sancuso.com.
Granisetron wikiPageID "429616".
Granisetron wikiPageRevisionID "600050524".
Granisetron atcPrefix "A04".
Granisetron atcSuffix "AA02".
Granisetron bioavailability "60.0".
Granisetron c "18".
Granisetron casNumber "109889".
Granisetron chebi "5537".
Granisetron chembl "519643".
Granisetron chemspiderid "10482033".
Granisetron drugbank "DB00889".
Granisetron eliminationHalfLife "50400.0".
Granisetron excretion "Renal 11–12%, faecal 38%".
Granisetron h "24".
Granisetron hasPhotoCollection Granisetron.
Granisetron image "Granisetron_3D.png".
Granisetron inchi "1".
Granisetron iupacName "1".
Granisetron iupharLigand "2292".
Granisetron iupharLigand "2300".
Granisetron kegg "D04370".
Granisetron legalAu "S4".
Granisetron legalUk "POM".
Granisetron legalUs "Rx-only".
Granisetron medlineplus "a601211".
Granisetron metabolism "Hepatic".
Granisetron molecularWeight "312.41".
Granisetron n "4".
Granisetron o "1".
Granisetron pregnancyAu "B1".
Granisetron proteinBound "65.0".
Granisetron pubchem "3510".
Granisetron routesOfAdministration "Oral, intravenous, transdermal".
Granisetron smiles "CN4[C@@H]1CCC[C@H]4C[C@H]NCc3nnc2ccccc23".
Granisetron stdinchi "1".
Granisetron stdinchikey "MFWNKCLOYSRHCJ-BTTYYORXSA-N".
Granisetron tradename "Kytril".
Granisetron unii "WZG3J2MCOL".
Granisetron verifiedfields "changed".
Granisetron verifiedrevid "461123553".
Granisetron width "185".
Granisetron subject Category:5-HT3_antagonists.
Granisetron subject Category:Amides.
Granisetron subject Category:Antiemetics.
Granisetron subject Category:Cancer_treatments.
Granisetron subject Category:Indazoles.
Granisetron subject Category:Tropanes.
Granisetron type 5-HT3Antagonists.
Granisetron type Adversary109773245.
Granisetron type CausalAgent100007347.
Granisetron type LivingThing100004258.
Granisetron type Object100002684.
Granisetron type Organism100004475.
Granisetron type Person100007846.
Granisetron type PhysicalEntity100001930.
Granisetron type Whole100003553.
Granisetron type YagoLegalActor.
Granisetron type YagoLegalActorGeo.
Granisetron type Drug.
Granisetron type DrugProduct.
Granisetron type FunctionalSubstance.
Granisetron comment "Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata. It does not have much effect on vomiting due to motion sickness.".
Granisetron label "Granisetron".
Granisetron label "Granisetron".
Granisetron label "Granisetron".
Granisetron label "Granisetrona".
Granisetron label "Granisétron".
Granisetron label "グラニセトロン".
Granisetron sameAs Granisetron.
Granisetron sameAs Granisétron.
Granisetron sameAs Granisetron.
Granisetron sameAs グラニセトロン.
Granisetron sameAs Granisetrona.
Granisetron sameAs m.027h_w.
Granisetron sameAs Q596708.
Granisetron sameAs Q596708.
Granisetron sameAs Granisetron.
Granisetron sameAs DB00889.
Granisetron sameAs 3510.
Granisetron sameAs Granisetron.
Granisetron wasDerivedFrom Granisetron?oldid=600050524.
Granisetron depiction Granisetron.svg.
Granisetron isPrimaryTopicOf Granisetron.