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- Griffithsin abstract "Griffithsin is a protein isolated from the red algae Griffithsia. It has a 121-amino acid sequence which exhibits a Jacalin-like lectin fold. Several structures of this protein have been solved by X-ray crystallography and deposited in the PDB. It has been shown in vitro to be a highly potent HIV entry inhibitor. It is currently being investigated as a potential microbicide for use in the prevention of the transmission of HIV. Griffithsin shows a broad spectrum ability to bind to the glycoproteins of other viruses, such as the coronavirus. Griffithsin's three identical carbohydrate domains bind to specific oligosaccharides on the envelope of viral glycoproteins. This was demonstrated by in vitro and in vivo studies. For instance, it was shown that griffithsin binds to the SARS-CoV spike glycoprotein to inhibit entry of the SARS virus and thus inhibit infection. As reported in March 2009, Kenneth Palmer and coworkers modified the tobacco mosaic virus to incorporate the griffithsin gene and infected more than 9,300 tobacco plants. They were able to extract enough griffithsin to produce about 100,000 HIV microbicide doses from the leaves.".
- Griffithsin thumbnail 3ll2.png?width=300.
- Griffithsin wikiPageExternalLink searchResults.html?display=both&term=P84801.
- Griffithsin wikiPageID "14713488".
- Griffithsin wikiPageRevisionID "601802298".
- Griffithsin caption "Griffithsin in complex with a high-mannose branched carbohydrate. PDB".
- Griffithsin hasPhotoCollection Griffithsin.
- Griffithsin name "Griffithsin".
- Griffithsin organism "Griffithsia sp.".
- Griffithsin pdb "3".
- Griffithsin pdbSupplemental searchResults.html?display=both&term=P84801.
- Griffithsin symbol "GRTF".
- Griffithsin taxid "373036".
- Griffithsin uniprot "P84801".
- Griffithsin subject Category:Entry_inhibitors.
- Griffithsin subject Category:Proteins.
- Griffithsin type Abstraction100002137.
- Griffithsin type Chemical114806838.
- Griffithsin type Compound114818238.
- Griffithsin type Macromolecule114944888.
- Griffithsin type Material114580897.
- Griffithsin type Matter100020827.
- Griffithsin type Molecule114682133.
- Griffithsin type OrganicCompound114727670.
- Griffithsin type Part113809207.
- Griffithsin type PhysicalEntity100001930.
- Griffithsin type Protein114728724.
- Griffithsin type Proteins.
- Griffithsin type Relation100031921.
- Griffithsin type Substance100019613.
- Griffithsin type Thing100002452.
- Griffithsin type Unit109465459.
- Griffithsin comment "Griffithsin is a protein isolated from the red algae Griffithsia. It has a 121-amino acid sequence which exhibits a Jacalin-like lectin fold. Several structures of this protein have been solved by X-ray crystallography and deposited in the PDB. It has been shown in vitro to be a highly potent HIV entry inhibitor. It is currently being investigated as a potential microbicide for use in the prevention of the transmission of HIV.".
- Griffithsin label "Griffithsin".
- Griffithsin sameAs m.03gv0j9.
- Griffithsin sameAs Q5608941.
- Griffithsin sameAs Q5608941.
- Griffithsin sameAs Griffithsin.
- Griffithsin wasDerivedFrom Griffithsin?oldid=601802298.
- Griffithsin depiction 3ll2.png.
- Griffithsin isPrimaryTopicOf Griffithsin.
