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- HAS2 abstract "Hyaluronan synthase 2 is an enzyme that in humans is encoded by the HAS2 gene.Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded via ABC-Transporter into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.".
- HAS2 entrezgene "3037".
- HAS2 wikiPageID "14776575".
- HAS2 wikiPageRevisionID "591593762".
- HAS2 hasPhotoCollection HAS2.
- HAS2 requireManualInspection "no".
- HAS2 summaryText "Hyaluronan or hyaluronic acid is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded via ABC-Transporter into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase from Xenopus laevis, and human and murine hyaluronan synthase 1.".
- HAS2 updateCitations "yes".
- HAS2 updatePage "yes".
- HAS2 updateProteinBox "yes".
- HAS2 updateSummary "yes".
- HAS2 type Biomolecule.
- HAS2 type Protein.
- HAS2 type BiologicalObject.
- HAS2 comment "Hyaluronan synthase 2 is an enzyme that in humans is encoded by the HAS2 gene.Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds.".
- HAS2 label "HAS2".
- HAS2 sameAs m.03gxnkv.
- HAS2 sameAs Q5628960.
- HAS2 sameAs Q5628960.
- HAS2 wasDerivedFrom HAS2?oldid=591593762.
- HAS2 isPrimaryTopicOf HAS2.