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- HHEX abstract "Hematopoietically-expressed homeobox protein HHEX is a protein that in humans is encoded by the HHEX gene.This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation.The HHEX transcription factor acts as a promoter in some instances and an inhibitor others. It interacts with a number of other signaling molecules to play an important role in the development of multiple organs, such as the liver, thyroid and forebrain. HHEX serves to repress VEGFA, another protein which is important in endothelial cell development. SCL, a significant transcription factor for blood and endothelial cell differentiation, is shown to interact with HHEX to promote the correct development of the hematopoiesis process. HHEX appears to work together with another molecule, β-catenin, for the development of the anterior organizer. It also contributes to developmental remodeling and stabilization of endothelial cells in an unborn organism. The importance of this transcription factor is illustrated by the inability of HHEX knockout mice embryos to survive gestation. Without the expression of HHEX, these mice embryos die in utero between Day 13 and Day 16. HHEX knockout mice display a range of abnormalities including forebrain abnormalities in various levels of severity, as well as a number of other defects including heart, vasculature, liver, monocyte, and thyroid abnormalities.".
- HHEX entrezgene "3087".
- HHEX wikiPageID "14764246".
- HHEX wikiPageRevisionID "591643595".
- HHEX hasPhotoCollection HHEX.
- HHEX requireManualInspection "no".
- HHEX summaryText "The HHEX transcription factor acts as a promoter in some instances and an inhibitor others. It interacts with a number of other signaling molecules to play an important role in the development of multiple organs, such as the liver, thyroid and forebrain. HHEX serves to repress VEGFA, another protein which is important in endothelial cell development. SCL, a significant transcription factor for blood and endothelial cell differentiation, is shown to interact with HHEX to promote the correct development of the hematopoiesis process. HHEX appears to work together with another molecule, β-catenin, for the development of the anterior organizer. It also contributes to developmental remodeling and stabilization of endothelial cells in an unborn organism. The importance of this transcription factor is illustrated by the inability of HHEX knockout mice embryos to survive gestation. Without the expression of HHEX, these mice embryos die in utero between Day 13 and Day 16. HHEX knockout mice display a range of abnormalities including forebrain abnormalities in various levels of severity, as well as a number of other defects including heart, vasculature, liver, monocyte, and thyroid abnormalities.".
- HHEX summaryText "This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation.".
- HHEX updateCitations "yes".
- HHEX updatePage "yes".
- HHEX updateProteinBox "yes".
- HHEX updateSummary "yes".
- HHEX subject Category:Transcription_factors.
- HHEX type Abstraction100002137.
- HHEX type Beginning107290905.
- HHEX type Cause107326557.
- HHEX type Event100029378.
- HHEX type Factor107327805.
- HHEX type Happening107283608.
- HHEX type Origin107323922.
- HHEX type PsychologicalFeature100023100.
- HHEX type TranscriptionFactors.
- HHEX type YagoPermanentlyLocatedEntity.
- HHEX type Biomolecule.
- HHEX type Protein.
- HHEX type BiologicalObject.
- HHEX comment "Hematopoietically-expressed homeobox protein HHEX is a protein that in humans is encoded by the HHEX gene.This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation.The HHEX transcription factor acts as a promoter in some instances and an inhibitor others.".
- HHEX label "HHEX".
- HHEX sameAs m.021mt54.
- HHEX sameAs Q5629579.
- HHEX sameAs Q5629579.
- HHEX sameAs HHEX.
- HHEX wasDerivedFrom HHEX?oldid=591643595.
- HHEX isPrimaryTopicOf HHEX.