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- HLA-DR abstract "HLA-DR is a MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31. The complex of HLA-DR and its ligand, a peptide of 9 amino acids in length or longer, constitutes a ligand for the T-cell receptor (TCR). HLA (human leukocyte antigens) were originally defined as cell surface antigens that mediate graft-versus-host disease, which resulted in the rejection of tissue transplants in HLA-mismatched donors. Identification of these antigens has led to greater success and longevity in organ transplant.HLA-DR is also involved in several autoimmune conditions, disease susceptibility and disease resistance. It is also closely linked to HLA-DQ and this linkage often makes it difficult to resolve the more causative factor in disease.HLA-DR molecules are upregulated in response to signalling. In the instance of an infection, the peptide (such as the staphylococcal enterotoxin I peptide) is bound into a DR molecule and presented to a few of a great many T-cell receptors found on T-helper cells. These cells then bind to antigens on the surface of B-cells stimulating B-cell proliferation.".
- HLA-DR thumbnail DR_Illustration.PNG?width=300.
- HLA-DR wikiPageID "5812801".
- HLA-DR wikiPageRevisionID "574708967".
- HLA-DR function "Immune recognition and".
- HLA-DR function "antigen presentation".
- HLA-DR gene HLA-DRA.
- HLA-DR gene HLA-DRB1.
- HLA-DR gene HLA-DRB3_(gene).
- HLA-DR gene HLA-DRB4.
- HLA-DR gene HLA-DRB5.
- HLA-DR hasPhotoCollection HLA-DR.
- HLA-DR heteropolymer "MHC class II, DR".
- HLA-DR imageSource "Illustration of DR with bound ligand".
- HLA-DR locus "" "".
- HLA-DR locus "Chromosome 6p21.31".
- HLA-DR polymerType "heterodimer".
- HLA-DR proteinType Cell_surface_receptor.
- HLA-DR requireManualInspection "no".
- HLA-DR subunit "α".
- HLA-DR subunit "β1".
- HLA-DR subunit "β3".
- HLA-DR subunit "β4".
- HLA-DR subunit "β5".
- HLA-DR subunitcount "5".
- HLA-DR updateCitations "yes".
- HLA-DR updatePage "yes".
- HLA-DR updateProteinBox "yes".
- HLA-DR updateSummary "no".
- HLA-DR subject Category:Genes_on_chromosome_6.
- HLA-DR subject Category:HLA-DR_haplotypes.
- HLA-DR subject Category:Human_MHC_mediated_diseases.
- HLA-DR subject Category:MHC_Class_II.
- HLA-DR type Abstraction100002137.
- HLA-DR type Arrangement107938773.
- HLA-DR type Collection107951464.
- HLA-DR type Combination107963711.
- HLA-DR type Gene105436752.
- HLA-DR type GenesOnChromosome6.
- HLA-DR type Group100031264.
- HLA-DR type HLA-DRHaplotypes.
- HLA-DR type Haplotype105439582.
- HLA-DR type Ordering108456993.
- HLA-DR type Sequence108459252.
- HLA-DR type Series108457976.
- HLA-DR comment "HLA-DR is a MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31. The complex of HLA-DR and its ligand, a peptide of 9 amino acids in length or longer, constitutes a ligand for the T-cell receptor (TCR). HLA (human leukocyte antigens) were originally defined as cell surface antigens that mediate graft-versus-host disease, which resulted in the rejection of tissue transplants in HLA-mismatched donors.".
- HLA-DR label "HLA-DR".
- HLA-DR sameAs m.0f6lpz.
- HLA-DR sameAs Q5630163.
- HLA-DR sameAs Q5630163.
- HLA-DR sameAs HLA-DR.
- HLA-DR wasDerivedFrom HLA-DR?oldid=574708967.
- HLA-DR depiction DR_Illustration.PNG.
- HLA-DR isPrimaryTopicOf HLA-DR.
