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- HMG-CoA_synthase abstract "In molecular biology, HMG-CoA synthase EC 2.3.3.10 is an enzyme which catalyzes the reaction in which Acetyl-CoA condenses with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). It is the second reaction in the mevalonate-dependent isoprenoid biosynthesis pathway. HMG-CoA is an intermediate in both cholesterol synthesis and ketogenesis. This reaction is over-activated in patients with diabetes mellitus type 1 if left untreated, due to prolonged insulin deficiency and the exhaustion of substrates for gluconeogenesis and the TCA cycle, notably oxaloacetate. This results in shunting of excess acetyl-CoA into the ketone synthesis pathway via HMG-CoA, leading to the development of diabetic ketoacidosis.".
- HMG-CoA_synthase arm "p".
- HMG-CoA_synthase band "13".
- HMG-CoA_synthase band "14".
- HMG-CoA_synthase chromosome "1".
- HMG-CoA_synthase chromosome "5".
- HMG-CoA_synthase ecNumber "2.3.3.10".
- HMG-CoA_synthase entrezgene "3157".
- HMG-CoA_synthase entrezgene "3158".
- HMG-CoA_synthase hgncid "5007".
- HMG-CoA_synthase hgncid "5008".
- HMG-CoA_synthase locusSupplementaryData "-p12".
- HMG-CoA_synthase locusSupplementaryData "-p13".
- HMG-CoA_synthase omim "142940".
- HMG-CoA_synthase omim "600234".
- HMG-CoA_synthase refseq "NM_002130".
- HMG-CoA_synthase refseq "NM_005518".
- HMG-CoA_synthase symbol "HMGCS".
- HMG-CoA_synthase symbol "HMGCS1".
- HMG-CoA_synthase symbol "HMGCS2".
- HMG-CoA_synthase symbol "HMG_CoA_synt_C".
- HMG-CoA_synthase symbol "HMG_CoA_synt_N".
- HMG-CoA_synthase thumbnail PDB_1txt_EBI.jpg?width=300.
- HMG-CoA_synthase uniprot "P54868".
- HMG-CoA_synthase uniprot "Q01581".
- HMG-CoA_synthase wikiPageID "10940718".
- HMG-CoA_synthase wikiPageRevisionID "591674444".
- HMG-CoA_synthase altsymbols "HMGCS".
- HMG-CoA_synthase arm "p".
- HMG-CoA_synthase band "13".
- HMG-CoA_synthase band "14".
- HMG-CoA_synthase caption "staphylococcus aureus 3-hydroxy-3-methylglutaryl-coa synthase".
- HMG-CoA_synthase chromosome "1".
- HMG-CoA_synthase chromosome "5".
- HMG-CoA_synthase ecnumber "2.3".
- HMG-CoA_synthase entrezgene "3157".
- HMG-CoA_synthase entrezgene "3158".
- HMG-CoA_synthase hasPhotoCollection HMG-CoA_synthase.
- HMG-CoA_synthase hgncid "5007".
- HMG-CoA_synthase hgncid "5008".
- HMG-CoA_synthase interpro "IPR013528".
- HMG-CoA_synthase interpro "IPR013746".
- HMG-CoA_synthase locussupplementarydata "-p12".
- HMG-CoA_synthase locussupplementarydata "-p13".
- HMG-CoA_synthase name "3".
- HMG-CoA_synthase name "Hydroxymethylglutaryl-coenzyme A synthase C terminal".
- HMG-CoA_synthase name "Hydroxymethylglutaryl-coenzyme A synthase N terminal".
- HMG-CoA_synthase omim "142940".
- HMG-CoA_synthase omim "600234".
- HMG-CoA_synthase pfam "PF01154".
- HMG-CoA_synthase pfam "PF08540".
- HMG-CoA_synthase pfamClan "CL0046".
- HMG-CoA_synthase prosite "PDOC00942".
- HMG-CoA_synthase refseq "NM_002130".
- HMG-CoA_synthase refseq "NM_005518".
- HMG-CoA_synthase symbol "HMGCS1".
- HMG-CoA_synthase symbol "HMGCS2".
- HMG-CoA_synthase symbol "HMG_CoA_synt_C".
- HMG-CoA_synthase symbol "HMG_CoA_synt_N".
- HMG-CoA_synthase uniprot "P54868".
- HMG-CoA_synthase uniprot "Q01581".
- HMG-CoA_synthase subject Category:EC_2.3.3.
- HMG-CoA_synthase subject Category:Protein_families.
- HMG-CoA_synthase type Abstraction100002137.
- HMG-CoA_synthase type Family108078020.
- HMG-CoA_synthase type Group100031264.
- HMG-CoA_synthase type Organization108008335.
- HMG-CoA_synthase type ProteinFamilies.
- HMG-CoA_synthase type SocialGroup107950920.
- HMG-CoA_synthase type Unit108189659.
- HMG-CoA_synthase type YagoLegalActor.
- HMG-CoA_synthase type YagoLegalActorGeo.
- HMG-CoA_synthase type YagoPermanentlyLocatedEntity.
- HMG-CoA_synthase type Biomolecule.
- HMG-CoA_synthase type Protein.
- HMG-CoA_synthase type ProteinMolecule.
- HMG-CoA_synthase type BiologicalObject.
- HMG-CoA_synthase comment "In molecular biology, HMG-CoA synthase EC 2.3.3.10 is an enzyme which catalyzes the reaction in which Acetyl-CoA condenses with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). It is the second reaction in the mevalonate-dependent isoprenoid biosynthesis pathway. HMG-CoA is an intermediate in both cholesterol synthesis and ketogenesis.".
- HMG-CoA_synthase label "HMG-CoA synthase".
- HMG-CoA_synthase label "Hydroxymethylglutaryl-Coenzym A-Synthase".
- HMG-CoA_synthase label "Hydroxyméthylglutaryl-CoA synthase".
- HMG-CoA_synthase sameAs Hydroxymethylglutaryl-Coenzym_A-Synthase.
- HMG-CoA_synthase sameAs Hydroxyméthylglutaryl-CoA_synthase.
- HMG-CoA_synthase sameAs m.02qvngr.
- HMG-CoA_synthase sameAs Q409147.
- HMG-CoA_synthase sameAs Q409147.
- HMG-CoA_synthase sameAs HMG-CoA_synthase.
- HMG-CoA_synthase wasDerivedFrom HMG-CoA_synthase?oldid=591674444.
- HMG-CoA_synthase depiction PDB_1txt_EBI.jpg.
- HMG-CoA_synthase isPrimaryTopicOf HMG-CoA_synthase.
- HMG-CoA_synthase name "3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)".
- HMG-CoA_synthase name "3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)".
