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- HSUR abstract "HSURs (Herpesvirus saimiri U RNAs) are viral small regulatory RNAs. They are found in Herpesvirus saimiri which is responsible for aggressive T-cell leukemias in primates. They are nuclear RNAs which bind host proteins to form small nuclear ribonucleoproteins (snRNPs). The RNAs are 114-143 nucleotides in length and the HSUR family has been subdivided into HSURs numbered 1 to 7. The function of HSURs has not yet been identified; they do not affect transcription so are thought to act post-transcriptionally, potentially influencing the stability of host mRNAs.HSUR1 and 2 are the most conserved members of the family within HSV subgroups. HSUR1 has been shown to bind the host heterogeneous ribonucleoprotein particle protein hnRNPD in vivo. Other HSURs bind HuR/ELAVL1. They are transcribed by RNA polymerase II with promoters similar to that of U RNAsFeatures shared by all HSURs include: 5´-trimethylguanosine caps 3' terminal stem-loops canonical Sm protein-binding site (AUUUUUG)A proposed role for HSURs is that they use the RNAi pathway to manipulate host-cell gene expression. One identified miRNA which responds to HSURs is miR-27.".
- HSUR thumbnail HSUR1_SScons.png?width=300.
- HSUR wikiPageExternalLink pmidlookup?view=long&pmid=2164602.
- HSUR wikiPageExternalLink S0042-6822(85)71172-5.
- HSUR wikiPageExternalLink S0092-8674(88)80004-7.
- HSUR wikiPageExternalLink pmidlookup?view=long&pmid=15121869.
- HSUR wikiPageExternalLink pmidlookup?view=long&pmid=1315960.
- HSUR wikiPageExternalLink pmidlookup?view=long&pmid=2537954.
- HSUR wikiPageExternalLink pmidlookup?view=long&pmid=9334320.
- HSUR wikiPageExternalLink pmidlookup?view=long&pmid=1311093.
- HSUR wikiPageID "28351752".
- HSUR wikiPageRevisionID "591723869".
- HSUR caption "Conserved secondary structure of HSUR1.".
- HSUR caption "Conserved secondary structure of HSUR2.".
- HSUR hasPhotoCollection HSUR.
- HSUR name "HSUR1".
- HSUR name "HSUR2".
- HSUR rfam "RF01802".
- HSUR rnaType Small_nuclear_RNA.
- HSUR symbol "HSUR1".
- HSUR symbol "HSUR2".
- HSUR taxDomain "Herpesvirus saimiri, Herpesvirus ateles".
- HSUR subject Category:Gammaherpesvirinae.
- HSUR subject Category:Non-coding_RNA.
- HSUR comment "HSURs (Herpesvirus saimiri U RNAs) are viral small regulatory RNAs. They are found in Herpesvirus saimiri which is responsible for aggressive T-cell leukemias in primates. They are nuclear RNAs which bind host proteins to form small nuclear ribonucleoproteins (snRNPs). The RNAs are 114-143 nucleotides in length and the HSUR family has been subdivided into HSURs numbered 1 to 7.".
- HSUR label "HSUR".
- HSUR sameAs m.0crg2b_.
- HSUR sameAs Q5636006.
- HSUR sameAs Q5636006.
- HSUR wasDerivedFrom HSUR?oldid=591723869.
- HSUR depiction HSUR1_SScons.png.
- HSUR isPrimaryTopicOf HSUR.
