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- Halichondrin_B abstract "Halichondrin B is a large naturally occurring polyether macrolide originally isolated from the marine sponge Halichondria okadai by Hirata and Uemura in 1986. In the same report, these authors also reported the exquisite anticancer activity of halichondrin B against murine cancer cells both in culture and in in vivo studies. Halichondrin B was highly prioritized for development as a novel anticancer therapeutic by the United States National Cancer Institute and, in 1991, was the original test case for identification of mechanism of action (in this case, tubulin-targeted mitotic inhibitor) by NCI's then-brand-new "60-cell line screen" The complete chemical synthesis of halichondrin B was achieved by Yoshito Kishi and colleagues at Harvard University in 1992, an achievement that ultimately enabled the discovery and development of the structurally simplified and pharmaceutically optimized analog eribulin (E7389, ER-086526, NSC-707389). Eribulin was approved by the U.S. Food and Drug Administration on November 15, 2010, to treat patients with metastatic breast cancer who have received at least two prior chemotherapy regimens for late-stage disease, including both anthracycline- and taxane-based chemotherapies. Eribulin is marketed by Eisai Co. under the tradename Halaven.".
- Halichondrin_B iupacName "(1S,2S,2′S,3S,3aS,3a′S,5R,6S,7S,7′S,7aS,7a′S,9S,12S,14R,16R,18S,20S,22R,26R,28S,29S,30R,34R,37S,39R,40S,41R,43R,44S)-7,7′,14′′,29′′-tetramethyl-8′′,15′′-dimethylidene-2-(1,3,4-trihydroxybutyl)decahydro-3′H,32′′H-dispiro[furo[3,2-b]pyran-5,5′-furo[3,2-b]pyran-2′,24′′-[2,19,23,27,31,38,42,45,47,48,49]undecaoxaundecacyclo[32.9.2.1~3,40~.1~3,41~.1~6,9~.1~12,16]~.0~18,30~.0~20,28~.0~22,26~.0~37,44~.0~39,43~]nonatetracontan]-32′′-one".
- Halichondrin_B thumbnail Halichondrin_B.svg?width=300.
- Halichondrin_B wikiPageID "23544519".
- Halichondrin_B wikiPageRevisionID "605149543".
- Halichondrin_B hasPhotoCollection Halichondrin_B.
- Halichondrin_B imagefile "Halichondrin B.svg".
- Halichondrin_B imagesize "250".
- Halichondrin_B iupacname "-77".
- Halichondrin_B iupacnameHidden "yes".
- Halichondrin_B verifiedrevid "461766224".
- Halichondrin_B subject Category:Drugs.
- Halichondrin_B type Agent114778436.
- Halichondrin_B type CausalAgent100007347.
- Halichondrin_B type Drug103247620.
- Halichondrin_B type Drugs.
- Halichondrin_B type Matter100020827.
- Halichondrin_B type PhysicalEntity100001930.
- Halichondrin_B type Substance100020090.
- Halichondrin_B type ChemicalCompound.
- Halichondrin_B type ChemicalSubstance.
- Halichondrin_B type ChemicalObject.
- Halichondrin_B type Thing.
- Halichondrin_B comment "Halichondrin B is a large naturally occurring polyether macrolide originally isolated from the marine sponge Halichondria okadai by Hirata and Uemura in 1986. In the same report, these authors also reported the exquisite anticancer activity of halichondrin B against murine cancer cells both in culture and in in vivo studies.".
- Halichondrin_B label "Halichondrin B".
- Halichondrin_B label "ハリコンドリンB".
- Halichondrin_B sameAs ハリコンドリンB.
- Halichondrin_B sameAs m.06w2yxw.
- Halichondrin_B sameAs Q4993812.
- Halichondrin_B sameAs Q4993812.
- Halichondrin_B sameAs Halichondrin_B.
- Halichondrin_B wasDerivedFrom Halichondrin_B?oldid=605149543.
- Halichondrin_B depiction Halichondrin_B.svg.
- Halichondrin_B isPrimaryTopicOf Halichondrin_B.
