Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Hereditary_diffuse_leukoencephalopathy_with_spheroids> ?p ?o. }
Showing items 1 to 34 of
34
with 100 items per page.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids abstract "Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is a rare adult onset autosomal dominant disorder characterized by cerebral white matter degeneration with demyelination and axonal spheroids leading to progressive cognitive and motor dysfunction. Spheroids are axonal swellings with discontinuous or absence of myelin sheaths. It is believed that the disease arises from primary microglial dysfunction that leads to secondary disruption of axonal integrity, neuroaxonal damage, and focal axonal spheroids leading to demyelination. Spheroids in HDLS resemble to some extent those produced by shear stress in a closed head injury with damage to axons, causing them to swell due to blockage of axoplasmic transport. In addition to trauma, axonal spheroids can be found in aged brain, stroke, and in other degenerative diseases. In HDLS, it is uncertain whether demyelination occurs prior to the axonal spheroids or what triggers neurodegeneration after apparently normal brain and white matter development, although genetic deficits suggest that demyelination and axonal pathology may be secondary to microglial dysfunction. The clinical syndrome in patients with HDLS is not specific and it can be mistaken for Alzheimer's disease, frontotemporal dementia, atypical Parkinsonism, multiple sclerosis, or corticobasal degeneration.".
- Hereditary_diffuse_leukoencephalopathy_with_spheroids omim "221820".
- Hereditary_diffuse_leukoencephalopathy_with_spheroids wikiPageID "34231074".
- Hereditary_diffuse_leukoencephalopathy_with_spheroids wikiPageRevisionID "591709236".
- Hereditary_diffuse_leukoencephalopathy_with_spheroids hasPhotoCollection Hereditary_diffuse_leukoencephalopathy_with_spheroids.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids name "Hereditary diffuse leukoencephalopathy with spheroids".
- Hereditary_diffuse_leukoencephalopathy_with_spheroids omim "221820".
- Hereditary_diffuse_leukoencephalopathy_with_spheroids subject Category:Genetic_disorders.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids subject Category:Neurological_disorders.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids type Abstraction100002137.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids type Attribute100024264.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids type Condition113920835.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids type Disease114070360.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids type Disorder114052403.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids type GeneticDisease114151139.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids type GeneticDisorders.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids type IllHealth114052046.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids type Illness114061805.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids type NervousDisorder114084880.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids type NeurologicalDisorders.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids type PathologicalState114051917.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids type PhysicalCondition114034177.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids type State100024720.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids type Disease.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids type Situation.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids comment "Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is a rare adult onset autosomal dominant disorder characterized by cerebral white matter degeneration with demyelination and axonal spheroids leading to progressive cognitive and motor dysfunction. Spheroids are axonal swellings with discontinuous or absence of myelin sheaths.".
- Hereditary_diffuse_leukoencephalopathy_with_spheroids label "Hereditary diffuse leukoencephalopathy with spheroids".
- Hereditary_diffuse_leukoencephalopathy_with_spheroids sameAs m.0hzqnk2.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids sameAs Q5737835.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids sameAs Q5737835.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids sameAs Hereditary_diffuse_leukoencephalopathy_with_spheroids.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids wasDerivedFrom Hereditary_diffuse_leukoencephalopathy_with_spheroids?oldid=591709236.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids isPrimaryTopicOf Hereditary_diffuse_leukoencephalopathy_with_spheroids.
- Hereditary_diffuse_leukoencephalopathy_with_spheroids name "Hereditary diffuse leukoencephalopathy with spheroids (HDLS)".