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- High-content_screening abstract "High content screening (HCS) also known as high content analysis (HCA), or visual screening is a method that is used in biological research and drug discovery to identify substances such as small molecules, peptides, or RNAi that alter the phenotype of a cell in a desired manner. Hence high content screening is a type of phenotypic screen conducted in cells. Phenotypic changes may include increases or decreases in the production of cellular products such as proteins and/or changes in the morphology (visual appearance) of the cell. High content screening includes any method used to analyze whole cells or components of cells with simultaneous readout of several parameters. Hence the name "high content screening".In high content screening, cells are first incubated with the substance and after a period of time, structures and molecular components of the cells are analyzed. The most common analysis involves labeling proteins with fluorescent tags, and finally changes in cell phenotype are measured using automated image analysis. Through the use of fluorescent tags with different absorption and emission maxima, it is possible to measure several different cell components in parallel. Furthermore, the imaging is able to detect changes at a subcellular level (e.g., cytoplasm vs. nucleus vs. other organelles). Therefore a large number of data points can be collected per cell. In addition to fluorescent labeling, various label free assays have been used in high content screening.".
- High-content_screening thumbnail Pills_on_uv_box.jpg?width=300.
- High-content_screening wikiPageExternalLink MSSR.Pharmacology.UCLA.EDU.
- High-content_screening wikiPageExternalLink highcontent.
- High-content_screening wikiPageExternalLink hcs-analyzer.ip-korea.org.
- High-content_screening wikiPageExternalLink htbc.stanford.edu.
- High-content_screening wikiPageExternalLink liebel-lab.org.
- High-content_screening wikiPageExternalLink rnaiatlas.ethz.ch.
- High-content_screening wikiPageExternalLink sen.sourceforge.net.
- High-content_screening wikiPageExternalLink hcs-analyzer.
- High-content_screening wikiPageExternalLink index.html.
- High-content_screening wikiPageExternalLink highcontentscreening2.html.
- High-content_screening wikiPageExternalLink www.cdriindia.org.
- High-content_screening wikiPageExternalLink www.cellclassifier.org.
- High-content_screening wikiPageExternalLink index.htm.
- High-content_screening wikiPageExternalLink www.highcontentanalysis.com.
- High-content_screening wikiPageExternalLink www.ip-korea.org.
- High-content_screening wikiPageExternalLink group_index.php?mNum=2&c_seq=3&g_seq=00&dept_code=00340.
- High-content_screening wikiPageExternalLink www.labautopedia.com.
- High-content_screening wikiPageExternalLink hp_research_interest.
- High-content_screening wikiPageExternalLink www.mpi-cbg.de.
- High-content_screening wikiPageExternalLink highcontent.2_Image_Technologies_and_Ins.
- High-content_screening wikiPageExternalLink htcb.
- High-content_screening wikiPageID "5824073".
- High-content_screening wikiPageRevisionID "606498354".
- High-content_screening hasPhotoCollection High-content_screening.
- High-content_screening subject Category:Drug_discovery.
- High-content_screening subject Category:Microscopy.
- High-content_screening comment "High content screening (HCS) also known as high content analysis (HCA), or visual screening is a method that is used in biological research and drug discovery to identify substances such as small molecules, peptides, or RNAi that alter the phenotype of a cell in a desired manner. Hence high content screening is a type of phenotypic screen conducted in cells.".
- High-content_screening label "High-content screening".
- High-content_screening sameAs m.0f7dml.
- High-content_screening sameAs Q5754482.
- High-content_screening sameAs Q5754482.
- High-content_screening wasDerivedFrom High-content_screening?oldid=606498354.
- High-content_screening depiction Pills_on_uv_box.jpg.
- High-content_screening isPrimaryTopicOf High-content_screening.
